Zinc Finger Proteins : From Atomic Contact to Cellular Function

Cover Page......Page 1
Inside Cover......Page 3
Copyright © 2005......Page 4
Contents......Page 5
Editors and Contributors......Page 7
Preface......Page 13
Abbreviations......Page 14
CHAPTER 1 - The Discovery of Zinc Fingers and Their Practical Applications in Gene Regulation: A Personal Account......Page 17
CHAPTER 2 - C2H2 Zinc Fingers As DNA Binding Domains......Page 23
CHAPTER 3 - TFIIIA: A Sophisticated Zinc Finger Protein......Page 30
CHAPTER 4 - GAGA: Structural Basis for Single Cys2His2 Zinc Finger-DNA Interaction......Page 36
CHAPTER 5 - The DNA-Binding Domain of GATA Transcription Factors—A Prototypical Type IV Cys2-Cys2 Zinc Finger......Page 42
CHAPTER 6 - MutM: Single C2C2 Zinc Finger-DNA Interaction......Page 47
CHAPTER 7 - Homing Endonuclease I-TevI: An Atypical Zinc Finger with a Novel Function......Page 51
CHAPTER 8 - Zinc Finger Interactions with Metals and Other Small Molecules......Page 55
CHAPTER 9 - Synthetic Zinc Finger Transcription Factors......Page 63
CHAPTER 10 - TFIIIA and p43: Binding to 5S Ribosomal RNA......Page 72
CHAPTER 11 - RNA Binding by Single Zinc Fingers......Page 82
CHAPTER 12 - Wig-1, a p53-Induced Zinc Finger Protein that Binds Double Stranded RNA......Page 92
CHAPTER 13 - Tandem CCCH Zinc Finger Proteins in mRNA Binding......Page 96
CHAPTER 14 - Ribosomal Zinc Finger Proteins: The Structure and the Function of Yeast YL37a......Page 107
CHAPTER 15 - LIM Domain and Its Binding to Target Proteins......Page 115
CHAPTER 16 - RING Finger-B Box-Coiled Coil (RBCC) Proteins As Ubiquitin Ligase in the Control of Protein Degradation and Gene Regulation......Page 122
CHAPTER 17 - Structure and Function of the CBP/p300 TAZ Domains......Page 130
CHAPTER 18 - A Zinc Ribbon Motif Is Essential for the Formation of Functional Tetrameric Protein Kinase CK2......Page 137
CHAPTER 19 - The FYVE Finger: A Phosphoinositide Binding Domain......Page 144
CHAPTER 20 - The BTB Domain Zinc Finger Proteins......Page 150
CHAPTER 21 - KRAB Zinc Finger Proteins: A Family of Repressors Mediating Heterochromatin-Associated Gene Silencing......Page 167
CHAPTER 22 - The Superfamily of SCAN Domain Containing Zinc Finger Transcription Factors......Page 172
CHAPTER 23 - Sp1 and Huntington’s Disease......Page 184
CHAPTER 24 - The Role of WT1 in Development and Disease......Page 190
CHAPTER 25 - Yin Yang 1......Page 198
CHAPTER 26 - The Multiple Cellular Functions of TFIIIA......Page 211
CHAPTER 27 - The Role of the Ikaros Gene Family in Lymphocyte Development......Page 216
CHAPTER 28 - Basonuclin: A Zinc Finger Protein of Epithelial Cells and Reproductive Germ Cells......Page 223
CHAPTER 29 - ZAS Zinc Finger Proteins: The Other κB-Binding Protein Family......Page 229
CHAPTER 30 - Role of GATA Factors in Development......Page 237
CHAPTER 31 - The Androgen Receptor and Spinal and Bulbar Muscular Atrophy......Page 248
CHAPTER 32 - The Role of XPA in DNA Repair......Page 255
CHAPTER 33 - MOF, an Acetyl Transferase Involved in Dosage Compensation in Drosophila, Uses a CCHC Finger for Substrate Recognition......Page 263
CHAPTER 34 - MDM2: RING Finger Protein and Regulator of p53......Page 268
CHAPTER 35 - The Zip Family of Zinc Transporters......Page 277
CHAPTER 36 - Apoptosis by Zinc Deficiency......Page 281
INDEX......Page 288
Back Cover......Page 292