Zebrafish

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This cutting-edge resource includes up-to-date information on zebrafish physiology and the tools used to study it, not only as a model species for studies of other vertebrates but with application for studies of human disease and aquatic toxicology. The utility of zebrafish for physiological research is based on several key features including i) a "fully" sequenced genome, ii) rapid (~3 month) generation times), iii) their capacity to produce large numbers of externally fertilized eggs, iv) optical transparency of embryos and larvae, and v) the applicability of reverse and forward genetics to assess gene function. Gene knockdown in embryos and the production of transgenic strains are now standard techniques being used to assess physiology. This book will be of keen interest not only to the typical readers of Fish Physiology but also to biomedical researchers, toxicologists and developmental biologists. Key Features* Integrates and synthesizes the biology of the zebrafish under one cover* Features contributions from the leading researchers in their fields * Reaches a wider audience of researchers and biologists with its broad inclusion of subjects relating to zebrafish physiology

Author(s): Steve F. Perry, Marc Ekker, Anthony P. Farrell and Colin J. Brauner (Eds.)
Series: Fish Physiology 29
Edition: 1
Publisher: Elsevier, Academic Press
Year: 2010

Language: English
Pages: 1-486

Content:
Zebrafish
Page iii

Copyright
Page iv

Contributors
Pages ix-x

Preface
Pages xi-xii
Steve F. Perry, Marc Ekker

1 - Genetic tools
Pages 1-23
Marc Ekker, Marie-Andrée Akimenko

2 - Organization and physiology of the zebrafish nervous system
Pages 25-80
Laure Bally-Cuif, Philippe Vernier

3 - Zebrafish vision: Structure and function of the zebrafish visual system
Pages 81-122
Stephan C.F. Neuhauss

4 - The zebrafish inner ear
Pages 123-171
Leila Abbas, Tanya T. Whitfield

5 - Endocrinology of zebrafish: A small fish with a large gene pool
Pages 173-247
Ellen R. Busby, Graeme J. Roch, Nancy M. Sherwood

6 - Developmental physiology of the zebrafish cardiovascular system
Pages 249-287
John D. Mably, Sarah J. Childs

7 - Respiration
Pages 289-309
Bernd Pelster, Brian Bagatto

8 - Ionic and acid–base regulation
Pages 311-344
Pung-Pung Hwang, Steve F. Perry

9 - The zebrafish as a model for human disease
Pages 345-365
Cong Xu, Leonard I. Zon

10 - Perspectives on zebrafish as a model in environmental toxicology
Pages 367-439
John J. Stegeman, Jared V. Goldstone, Mark E. Hahn

Index
Pages 441-452