First published in 2006, the bestselling Wintrobe’s Atlas of Clinical Hematology has now been comprehensively updated by a brand-new editorial team to bring you state-of-the-art pictorial coverage of the complete range of hematologic conditions. Thousands of meticulous, full-color images capture the characteristic appearance of each pathologic entity, and concise descriptions point out features of diagnostic importance. The result is a peerless reference to facilitate confident diagnosis in hematology.
Features:
Access the latest knowledge in the field with more than 30% new or updated content – including expanded coverage of acute lymphoblastic leukemia (ALL); revised diagnostic criteria for fluorescent in situ hybridization (FISH); enhanced information on flow cytometry; new coverage of genetic screens, circulating DNA analysis, RT-PCR, exosome analysis, and evaluation of epigenetic abnormalities; completely new chapters on hemostasis and platelets as well as on plasma cell disorders and on benign diseases of leukocytes, spleen, and immunoglobins; and much more.
Vividly visualize the presentation of every hematologic disorder thanks to thousands of crisp, full-color images, hundreds of them new to this edition.
Locate the information you need more easily through a new, highly templated format that expedites navigation, as well as a new index of figures by disorder.
Easily find additional in-depth answers inside Wintrobe’s Clinical Hematology , the best-selling comprehensive reference in the field, since this Atlas now features a parallel organization.
Your book purchase includes a complimentary download of the enhanced eBook for iOS, Android, PC & Mac. Take advantage of these practical features that will improve your eBook experience:
The ability to download the eBook on multiple devices at one time — providing a seamless reading experience online or offline
Powerful search tools and smart navigation cross-links that allow you to search within this book, or across your entire library of VitalSource eBooks
Multiple viewing options that enable you to scale images and text to any size without losing page clarity as well as responsive design
The ability to highlight text and add notes with one click
Author(s): Babette Weksler, Geraldine P Schechter, Scott Ely
Series: Eğitim Tanrısı
Edition: 2nd Edition
Publisher: LWW
Year: 2017
Language: English
Commentary: CONVERTED PDF
Pages: 714
City: Ankara
Tags: Hematology
Contents......Page 5
Contributing Authors......Page 7
Preface......Page 10
Acknowledgments......Page 12
Slide Preparation and Staining......Page 13
Slide Examination......Page 14
EXAMINATION OF THE BONE MARROW ASPIRATE SMEAR AND TOUCH PREPARATION......Page 15
Slide Preparation and Staining......Page 16
Processing for Histologic Sections......Page 17
Slide Examination......Page 18
2. Techniques for Assessing Blood Disorders......Page 70
MULTIPARAMETER FLOW CYTOMETRY......Page 71
Clinical Indications for Flow Cytometry......Page 72
Flow Cytometric Analysis Specimen Processing......Page 73
Antibodies: Compensation and Panel Design......Page 75
Data Acquisition......Page 76
Data Analysis......Page 77
Data Reporting......Page 78
MFC for Nonneoplastic Disorders......Page 79
General Approach to Detecting Neoplastic Myeloid Cells by MFC......Page 80
MFC for Diagnosis in Myelodysplasia and Myeloproliferative Neoplasms......Page 81
MFC in Specific AML Subtypes......Page 82
MFC for Precursor Lymphoid Neoplasms......Page 83
MFC for B-Cell Non-Hodgkin Lymphoma......Page 84
Lymphoplasmacytic Lymphoma......Page 85
T-Cell Neoplasm Diagnosis by MFC......Page 86
T-Cell Large Granular Lymphocyte Leukemia......Page 87
NK Cell Neoplasm Diagnosis by MFC......Page 88
Plasma Cell Neoplasm Diagnosis by MFC......Page 89
MFC to Detect Circulating Tumor Cells from Solid Organ Cancers......Page 90
FINE-NEEDLE ASPIRATION AND CYTOLOGY......Page 91
MULTIPLEX IMMUNOHISTOCHEMISTRY......Page 92
mIHC for Diagnosis in Plasma Cell Neoplasms, Including Myeloma, MGUS, and Amyloidosis......Page 93
Reticulin and Masson Trichrome......Page 94
PCR for Lymphoma Diagnosis......Page 95
Reverse Transcriptase PCR for PML-RARA in AML with t(15;17) Acute Promyelocytic Leukemia......Page 96
PCR Fragment Length Analysis for Prognostication and Subtyping in AML: Nucleophosmin 1, CCAAT Enhancer Binding Protein, and FMS-like Tyrosine Kinase 3......Page 97
EPIGENETIC ABNORMALITIES......Page 98
REFERENCES......Page 99
3. Anemia......Page 145
Anemia of Iron Deficiency......Page 146
Megaloblastic Anemia......Page 149
Nonmegaloblastic Macrocytic Anemia......Page 152
Anemia of Endocrine Disorders......Page 153
Pure Red Cell Aplasia......Page 154
HEMOLYTIC ANEMIAS......Page 155
HEMOGLOBINOPATHIES AND THALASSEMIAS......Page 157
REFERENCES......Page 159
Hemostasis......Page 241
Fibrinolysis......Page 242
Thrombocytopenia......Page 243
Inherited Factor Deficiencies......Page 246
Hemophilia C: Factor XI Deficiency......Page 248
Acquired Factor Deficiencies......Page 249
Hypercoagulable State and Cancer......Page 250
Factor V Leiden and Factor II (Prothrombin Gene) G20210A Variants......Page 251
Heparin-Induced Thrombocytopenia......Page 252
Thrombotic Thrombocytopenic Purpura......Page 253
BLEEDING RELATED TO VASCULAR ABNORMALITIES......Page 254
REFERENCES......Page 255
Neutrophilia......Page 292
Neutropenia......Page 293
Lymphocytosis......Page 295
Monocytosis......Page 296
Eosinophilia......Page 297
NONNEOPLASTIC DISEASES OF THE SPLEEN......Page 298
Primary Immunodeficiency Disorders......Page 300
Hypergammaglobulinemia......Page 301
REFERENCES......Page 302
6. Acute Leukemias......Page 334
AML with Recurrent Genetic Abnormalities......Page 336
AML Not Otherwise Categorized......Page 337
Acute Leukemias of Ambiguous Lineage......Page 338
REFERENCES......Page 339
7. Myelodysplastic Syndromes......Page 435
MDS WITH EXCESS BLASTS......Page 438
MYELODYSPLASTIC SYNDROME, UNCLASSIFIABLE......Page 439
REFERENCES......Page 440
8. Myeloproliferative Neoplasms......Page 460
CHRONIC MYELOID LEUKEMIA, BCR-ABL1-POSITIVE......Page 461
POLYCYTHEMIA VERA......Page 463
PRIMARY MYELOFIBROSIS......Page 465
ESSENTIAL THROMBOCYTHEMIA......Page 468
CHRONIC EOSINOPHILIC LEUKEMIA, NOT OTHERWISE SPECIFIED......Page 469
REFERENCES......Page 470
B-Cell Ontogeny and the Mature B-Cell Neoplasms......Page 523
Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma......Page 524
Follicular Lymphoma......Page 525
Mediastinal Large B-Cell Lymphoma......Page 526
Marginal Zone Lymphoma......Page 527
Nodal Marginal Zone Lymphoma......Page 528
Waldenström Macroglobulinemia (Lymphoplasmacytic Lymphoma)......Page 529
MATURE T-CELL AND NK-CELL NEOPLASMS......Page 530
Aggressive NK-Cell Leukemia......Page 531
Extranodal NK-/T-Cell Lymphoma, Nasal Type......Page 532
Mycosis Fungoides and Sézary Syndrome......Page 533
Anaplastic Large-Cell Lymphoma, ALK-Positive......Page 534
HODGKIN LYMPHOMA......Page 535
Mixed Cellularity Hodgkin Lymphoma......Page 536
BIBLIOGRAPHY......Page 537
10. Plasma Cell Disorders......Page 630
MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE......Page 631
MULTIPLE MYELOMA......Page 632
AL (PRIMARY) AMYLOIDOSIS AND POEMS......Page 634
SOLITARY PLASMACYTOMA......Page 635
REFERENCES......Page 636
A......Page 663
B......Page 667
C......Page 673
E......Page 676
F......Page 678
G......Page 679
H......Page 680
I......Page 683
K......Page 684
L......Page 685
M......Page 687
N......Page 695
P......Page 697
R......Page 700
S......Page 702
T......Page 704
W......Page 706
X......Page 707
