WHO Classification of Tumours of the Central Nervous System

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Author(s): David N. Louis, Hiroko Ohgaki, Otmar D. Wiestier, Webster K. Cavenee, David W. Ellison, Dominique Figarella-Branger, Arie Perry, Guido Reifenberger, Andreas von Deimling
Edition: Revised 4th
Publisher: International Agency for Research on Cancer (IARC)
Year: 2016

Language: English
Pages: 409

Contents
WHO classification of tumours of the central nervous system
Introduction: WHO classification and grading of tumours of the central nervous system
Chapter 1: Diffuse astrocytic and oligodendroglial tumours
Introduction
Diffuse astrocytoma, IDH-mutant
Gemistocytic astrocytoma, IDH-mutant
Diffuse astrocytoma, IDH-wildtype
Diffuse astrocytoma, NOS
Anaplastic astrocytoma, IDH-mutant
Anaplastic astrocytoma, IDH-wildtype
Anaplastic astrocytoma, NOS
Glioblastoma, IDH-wildtype
Giant cell glioblastoma
Gliosarcoma
Epithelioid glioblastoma
Glioblastoma, IDH-mutant
Glioblastoma, NOS
Diffuse midline glioma, H3 K27M-mutant
Oligodendroglioma, IDH-mutant and 1p/19q-codeleted
Oligodendroglioma, NOS
Anaplastic oligodendroglioma, IDH-mutant and 1p/19q-codeleted
Anaplastic oligodendroglioma, NOS
Oligoastrocytoma, NOS
Anaplastic oligoastrocytoma, NOS
Chapter 2: Other astrocytic tumours
Pilocytic astrocytoma
Pilomyxoid astrocytoma
Subependymal giant cell astrocytoma
Pleomorphic xanthoastrocytoma
Anaplastic pleomorphic xanthoastrocytoma
Chapter 3: Ependymal tumours
Subependymoma
Myxopapillary ependymoma
Ependymoma
Papillary ependymoma
Clear cell ependymoma
Tanycytic ependymoma
Ependymoma, RELA fusion-positive
Anaplastic ependymoma
Chapter 4: Other gliomas
Chordoid glioma of the third ventricle
Angiocentric glioma
Astroblastoma
Chapter 5: Choroid plexus tumours
Choroid plexus papilloma
Atypical choroid plexus papilloma
Choroid plexus carcinoma
Chapter 6: Neuronal and mixed neuronal–glial tumours
Dysembryoplastic neuroepithelial tumour
Gangliocytoma
Ganglioglioma
Anaplastic ganglioglioma
Dysplastic cerebellar gangliocytoma (Lhermitte-Duclos disease)
Desmoplastic infantile astrocytoma andganglioglioma
Papillary glioneuronal tumour
Rosette-forming glioneuronal tumour
Diffuse leptomeningeal glioneuronal tumour
Central neurocytoma
Extraventricular neurocytoma
Cerebellar liponeurocytoma
Paraganglioma
Chapter 7: Tumours of the pineal region
Pineocytoma
Pineal parenchymal tumour of intermediate differentiation
Pineoblastoma
Papillary tumour of the pineal region
Chapter 8: Embryonal tumours
Medulloblastoma
Medulloblastoma, NOS
Medulloblastomas, genetically defined
Medulloblastoma, WNT-activated
Medulloblastoma, SHH-activated and TP53-mutant
Medulloblastoma, SHH-activated and TP53-wildtype
Medulloblastoma, non-WNT/non-SHH
Medulloblastomas, histologically defined
Medulloblastoma, classic
Desmoplastic/nodularmedulloblastoma
Medulloblastoma with extensive nodularity
Large cell/anaplastic medulloblastoma
Embryonal tumour with multilayered rosettes, C19MC-altered
Embryonal tumour with multilayered rosettes, NOS
Other CNS embryonal tumours
Medulloepithelioma
CNS neuroblastoma
CNS ganglioneuroblastoma
CNS embryonal tumour, NOS
Atypical teratoid/rhabdoid tumour
CNS embryonal tumour with rhabdoid features
Chapter 9: Tumours of the cranial and paraspinal nerves
Schwannoma
Cellular schwannoma
Plexiform schwannoma
Melanotic schwannoma
Neurofibroma
Atypical neurofibroma
Plexiform neurofibroma
Perineurioma
Hybrid nerve sheath tumours
Malignant peripheral nerve sheath tumour
Malignant peripheral nerve sheath tumour with divergent differentiation
Epithelioid malignant peripheral nerve sheath tumour
MPNST with perineurial differentiation (malignant perineurioma)
Chapter 10: Meningiomas
Meningioma
Meningioma variants
Meningothelial meningioma
Fibrous meningioma
Transitional meningioma
Psammomatous meningioma
Angiomatous meningioma
Microcystic meningioma
Secretory meningioma
Lymphoplasmacyte-rich meningioma
Metaplastic meningioma
Chordoid meningioma
Clear cell meningioma
Atypical meningioma
Papillary meningioma
Rhabdoid meningioma
Anaplastic (malignant) meningioma
Chapter 11: Mesenchymal, non-meningothelial tumours
Solitary fibrous tumour/haemangiopericytoma
Haemangioblastoma
Haemangioma
Epithelioid haemangioendothelioma
Angiosarcoma
Kaposi sarcoma
Ewing sarcoma/peripheral primitive neuroectodermal tumour
Lipoma
Angiolipoma
Hibernoma
Liposarcoma
Desmoid-type fibromatosis
Myofibroblastoma
Inflammatory myofibroblastic tumour
Benign fibrous histiocytoma
Fibrosarcoma
Undifferentiated pleomorphic sarcoma/malignant fibrous histiocytoma
Leiomyoma
Leiomyosarcoma
Rhabdomyoma
Rhabdomyosarcoma
Chondroma
Chondrosarcoma
Osteoma
Osteochondroma
Osteosarcoma
Chapter 12: Melanocytic tumours
Meningeal melanocytosis
Meningeal melanomatosis
Meningeal melanocytoma
Meningeal melanoma
Chapter 13: Lymphomas
Diffuse large B-cell lymphoma of the CNS
Corticoid-mitigated lymphoma
Sentinel lesions
Immunodeficiency-associated CNS lymphomas
AIDS-related diffuse large B-celllymphoma
EBV+ diffuse large B-cell lymphoma, NOS
Lymphomatoid granulomatosis
Intravascular large B-cell lymphoma
Miscellaneous rare lymphomas in the CNS
Low-grade B-cell lymphomas
T-cell and NK/T-cell lymphomas
Anaplastic large cell lymphoma
MALT lymphoma of the dura
Chapter 14: Histiocytic tumours
Langerhans cell histiocytosis
Erdheim-Chester disease
Rosai-Dorfman disease
Juvenile xanthogranuloma
Histiocytic sarcoma
Chapter 15: Germ cell tumours
Germinoma
Embryonal carcinoma
Yolk sac tumour
Choriocarcinoma
Teratoma
Mature teratoma
Immature teratoma
Teratoma with malignant transformation
Mixed germ cell tumour
Chapter 16: Familial tumour syndromes
Neurofibromatosis type 1
Neurofibromatosis type 2
Schwannomatosis
Von Hippel-Lindau disease
Tuberous sclerosis
Li-Fraumeni syndrome
Cowden syndrome
Turcot syndrome
Brain tumour-polyposissyndrome 1 (BTP1)/Mismatch repair cancer syndrome
Brain tumour-polyposissyndrome 2 (BTP2)/Familial adenomatous polyposis
Naevoid basal cell carcinoma syndrome
Rhabdoid tumour predisposition syndrome
Chapter 17: Tumours of the sellar region
Craniopharyngioma
Adamantinomatous craniopharyngioma
Papillary craniopharyngioma
Granular cell tumour of the sellar region
Pituicytoma
Spindle cell oncocytoma
Chapter 18: Metastatic tumours
Metastatic tumours of the CNS
Contributors
References
Subject index
Numbers
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
Q
R
S
T
U
V
W
Y
Z
List of abbreviations