The WHO Classification of Tumours of Endocrine Organs is the tenth volume in the 4th Edition of the WHO series on histological and genetic typing of human tumours.
This authoritative, concise reference book provides an international standard for oncologists and pathologists and will serve as an indispensable guide for use in the design of studies evaluating response to therapy and clinical outcome. Diagnostic criteria, pathological features, and associated genetic alterations are described in a disease-oriented manner. Sections on all recognized neoplasms and their variants include new ICD-O codes, epidemiology, clinical features, pathology, genetics, prognosis and predictive factors.
The book, prepared by 166 authors from 25 countries, contains more than 700 colour images and tables, and more than 3100 references.
Author(s): Ricardo V. Lloyd, Robert Y. Osamura, Günter Klöppel, Juan Rosai
Edition: 4
Publisher: International Agency for Research on Cancer
Year: 2017
Language: English
Pages: 283
Cover......Page 1
Contents......Page 3
CHAPTER 1 - Tumours of the pituitary gland......Page 5
WHO classification of tumours of the pituitary......Page 6
Pituitary adenoma......Page 8
Somatotroph adenoma......Page 13
Lactotroph adenoma......Page 18
Thyrotroph adenoma......Page 22
Corticotroph adenoma......Page 24
Gonadotroph adenoma......Page 28
Null cell adenoma......Page 31
Plurihormonal and double adenomas......Page 33
Pituitary carcinoma......Page 35
Pituitary blastoma......Page 39
Craniopharyngioma......Page 40
Neuronal and paraneuronal tumours......Page 42
Tumours of the posterior pituitary......Page 46
Mesenchymal and stromal tumours......Page 49
Haematolymphoid tumours......Page 54
Germ cell tumours......Page 55
Secondary tumours......Page 57
CHAPTER 2 - Tumours of the thyroid gland......Page 59
WHO classification of tumours of the thyroid gland......Page 60
TNM classification of tumours of the thyroid gland......Page 61
Follicular adenoma......Page 63
Hyalinizing trabecular tumour......Page 67
Other encapsulated follicular-patterned thyroid tumours......Page 69
Papillary thyroid carcinoma......Page 75
Follicular thyroid carcinoma......Page 86
Hurthle (oncocytic) cell tumours......Page 90
Poorly differentiated thyroid carcinoma......Page 94
Anaplastic thyroid carcinoma......Page 98
Squamous cell carcinoma......Page 101
Medullary thyroid carcinoma......Page 102
Mixed medullary and follicular thyroid carcinoma......Page 108
Mucoepidermoid carcinoma......Page 111
Sclerosing mucoepidermoid carcinoma with eosinophilia......Page 113
Mucinous carcinoma......Page 115
Ectopic thymoma......Page 116
Spindle epithelial tumour with thymus-like differentiation......Page 117
Intrathyroid thymic carcinoma......Page 119
Paraganglioma and mesenchymal / stromal tumours......Page 121
Haematolymphoid tumours......Page 129
Germ cell tumours......Page 133
Secondary tumours......Page 136
CHAPTER 3 - Tumours of the parathyroid glands......Page 138
WHO classification & TNM staging of tumours of the parathyroid glands......Page 139
Parathyroid carcinoma......Page 140
Parathyroid adenoma......Page 146
Secondary, mesenchymal and other tumours......Page 152
CHAPTER 4 - Tumours of the adrenal cortex......Page 153
WHO classification & TNM classification of tumours of the adrenal cortex......Page 154
Adrenal cortical carcinoma......Page 155
Adrenal cortical adenoma......Page 161
Sex cord-stromal tumours......Page 165
Adenomatoid tumour......Page 166
Mesenchymal and stromal tumours......Page 167
Haematolymphoid tumours......Page 169
Secondary tumours......Page 170
CHAPTER 5 - Tumours of the adrenal medulla and extra-adrenal paraganglia......Page 171
WHO classification & TNM staging of tumours of the adrenal medullaand extra-adrenal paraganglia......Page 172
Phaeochromocytoma......Page 175
Extra-adrenal paragangliomas......Page 182
Neuroblastic tumours of the adrenal gland......Page 188
Composite phaeochromocytoma......Page 196
Composite paraganglioma......Page 198
CHAPTER 6 - Neoplasms of the neuroendocrine pancreas......Page 200
WHO classification & TNM classification of neoplasms of theneuroendocrine pancreas......Page 201
Introduction......Page 202
Non-functioning (non-syndromic) neuroendocrine tumours......Page 206
lnsulinoma......Page 213
Glucagonoma......Page 216
Somatostatinoma......Page 218
Gastrinoma......Page 220
VIPoma......Page 222
Serotonin-producing tumours with and without carcinoid syndrome......Page 224
ACTH-producing tumour with Cushing syndrome......Page 225
Pancreatic neuroendocrine carcinoma (poorly differentiated neuroendocrine neoplasm)......Page 226
Mixed neuroendocrine - non-neuroendocrine neoplasms......Page 229
CHAPTER 7 - Inherited tumour syndromes......Page 231
Introduction......Page 232
Multiple endocrine neoplasia type 1......Page 233
Multiple endocrine neoplasia type 2......Page 238
Multiple endocrine neoplasia type 4......Page 243
Hyperparathyroidism-jaw tumour syndrome......Page 245
Von Hipel-Lindau syndrome......Page 247
Familial paraganglioma-phaeochromocytoma syndromes caused by SDHB, SDHC, and SDHD mutations......Page 252
Neurofibromatosis type 1......Page 256
Carney complex......Page 259
McCune-Albright syndrome......Page 262
Familial non-medullary thyroid cancer......Page 265
DICER1 syndrome......Page 270
Glucagon cell hyperplasia andneoplasia......Page 272
Subject index......Page 274
List of abbreviations......Page 282
