Werner & Ingbar's The Thyroid: A Fundamental and Clinical Text, 10th Edition has been extensively revised and streamlined to deliver the most comprehensive coverage of the thyroid including anatomy, development, biochemistry, physiology, pathophysiology, and treatment of all thyroid disorders. Entirely new chapters on the surgical management of thyroid cancer, thyroid disruptors, and thyroid hormone analogs are in this edition. New authors and an international group of contributors elevate this classic text that includes extensive clinical coverage of thyroid dysfunction's effects on other organ systems. Also addressed are clinical controversies regarding the ageing thyroid, subclinical hypothyroidism and hyperthyroidism and thyroid disease in pregnancy.
New to this edition:
- Twenty-three chapters authored by new contributors and international experts
- A companion website with fully searchable text for quick reference
- Three new chapters discuss surgical management of thyroid cancer, thyroid disruptors, and thyroid hormone analogs to keep you up-to-date on the latest advances in the field
"This is an update of the classic thyroid text and is clearly essential for endocrinologists and thyroid surgeons. It is certainly useful for those undertaking thyroid related research but it is clearly far too detailed for students other than those undertaking basic science research in the thyroid. This edition has added the surgical management of thyroid disorders which is clearly an asset for the endocrine surgeon. With this type of reference text it is inevitable that there will be information from many years ago cited. There has however been a clear effort to update information and expand detail including more up-to-date references -- studies related to markers of disease progression in thyroid cancer, cytopathology of thyroid cancer. Studies and other works that are references are of high quality and in general integral to the subject matter being discussed. There has also been a clear effort made to critically appraise the texts being cited. In general it is well written. Sections of the book can be a little monotonous only due to the subject matter i.e. thyroid hormone synthesis and thyroglobulin structure, function and biosynthesis. The diagrams and illustrations particularly in the basic science section are very useful. The use of colour images would have made them a lot more pleasing on the eye. Only for those subspecializing in thyroid disorders or conducting research into the thyroid gland. This book has helped me to understand the thyroid gland further and will continue to do so. It is the type of book one consults to answer a specific question and to provide context for a clinical problem." -- BMA Medical Book Award reviewer, 2013 BMA Medical Book Awards
Author(s): Lewis E. Braverman, David Cooper
Edition: 10
Publisher: LWW Wolters Kluwer
Year: 2012
Language: English
Commentary: TRUE PDF
Tags: Endocrinology & Metabolism; Thyroid Diseases
Title
Copyright
Preface
Contents
1
The Heritage of the Thyroid: A Brief History
2 Development of the Hypothalamic-Pituitary-Thyroid Axis
3
Anatomy and Pathology of the Thyrotrophs
4A
Thyroid Hormone Synthesis: Thyroid Iodide Transport
4B
Thyroid Hormone Synthesis
5 Thyroglobulin Structure, Function, and Biosynthesis
6 Thyroid Hormone Transport Proteins and the Physiology
of Hormone Binding
7 Intracellular Pathways of Iodothyronine Metabolism/Implications of Deiodination for Thyroid Hormone Action
8 Genomic and Nongenomic Actions of Thyroid Hormones
9
Thyroid Hormone Structure-Function Relationships
10A Chemistry and Biosynthesis of Thyrotropin
10B
The Thyrotropin Receptor
10C
Regulation of Thyrotropin Secretion
11A
Age Related Changes in Thyroid Function
11B Effects of Drugs on TSH Secretion, Thyroid Hormones
Absorption, Synthesis, Metabolism, and Action
11C
Nonthyroidal Illness Syndrome
11D
Iodine Deficiency and Endemic Cretinism
11E
Effect of Excess Iodide: Clinical Aspects
12
Thyroid Radionuclide Uptake and Imaging Studies
13A Measuring Serum Thyroid-Stimulating Hormone, Thyroid Hormones, Thyroid-Directed Antibodies, and
Transport Proteins
13B
Measurement of Thyroglobulin
14
Nonisotopic Techniques of Thyroid Imaging
15
Physical Examination of the Thyroid Gland
16
Pathology and Cytopathology
17
Introduction to Thyrotoxicosis
18A
Pathogenesis of Graves' Disease
18B
Ophthalmopathy
18C
Thyroid Dermopathy and Thyroid Acropachy
19
Thyrotropin-Induced Thyrotoxicosis
20
Toxic Adenoma and Toxic Multinodular Goiter
21 Trophoblastic Tumors
22 Sporadic Painless, Painful Subacute and Acute Infectious Thyroiditis
23 Thyrotoxicosis of Extrathyroid Origin
24 Overview of the Clinical Manifestations of Thyrotoxicosis
25 The Cardiovascular System in Thyrotoxicosis
26 Thyroid Hormones in Thermogenesis, Intermediary Metabolism, and Obesity
27 The Male and Female Reproductive System in Thyrotoxicosis
28 The Skeletal System in Thyrotoxicosis
29 Behavioral and Psychiatric Aspects of Thyrotoxicosis
30 Thyrotoxic Storm
31 Diagnosis of Thyrotoxicosis
32 Treatment of Thyrotoxicosis
33 Subclinical Thyrotoxicosis
34 Introduction to Hypothyroidism
35 Chronic Autoimmune Thyroiditis
36 Genetic Defects Causing Hypothyroidism
37 Primary Hypothyroidism Due to Other Causes
38 Central Hypothyroidism
39 Overview of the Clinical Manifestations of Hypothyroidism
40 The Cardiovascular System in Hypothyroidism
41 The Male and Female Reproductive
System in Hypothyroidism
42 The Skeletal System in Hypothyroidism
42 Psychiatric and Cognitive Effects of
Hypothyroidism
44 Myxedema Coma
45
Diagnosis of Hypothyroidism
46 Treatment of Hypothyroidism
47 Subclinical Hypothyroidism
48 Multinodular Goiter: Pathogenesis and Management
49 Clinical Evaluation
and Management of Thyroid Nodules
50A Carcinomas of Follicular Epithelium: Epidemiology and Pathogenesis
50B Molecular Genetics of Tumors of Thyroid Follicular Cells
50C Carcinoma of the Follicular Epithelium: Surgery Therapy
50D Staging and Prognosis of Differentiated Thyroid Cancer
50E Medical Management of Differentiated Epithelial Cell Thyroid Cancer
51 Medullary Thyroid Carcinoma
52 Anaplastic Thyroid Cancer and Miscellaneous Tumors of the Thyroid
53 The Maturation of Thyroid Function in the Perinatal Period and During Childhood
54A Hypothyroidism in Infants and Children: Neonatal Screening
54B
Hypothyroidism in Infants and Children: Congenital Hypothyroidism
54C Hypothyroidism in Infants, Children, and Adolescents: Acquired Hypothyroidism
55 Hyperthyroidism in the Neonatal Period and Childhood
56 Thyroid Disorders During Pregnancy and Postpartum
57 Thyroid Disruptors
58 Reduced Sensitivity to Thyroid Hormone: Defects of Transport, Metabolism, and Action
Index
A
B
C
D
E
F
G
H
I
J
K
L
M
N
O
P
R
S
T
U
V
W
X
Y
Z
