The following chapters provide excellent and comprehensive discussions of the potential role of vitamin D based therapies in breast, colorectal, prostate cancer and leukemia and myelodysplastic syndromes. These chapters also point out that the focus on these diseases is largely determined by the interests and expertise of the outstanding scientists who have chosen to pursue vitamin D based cancer therapeutics. To our knowledge, every tumor type ever evaluated has shown some biochemical and antiproliferative response to vitamin D. Similarly, vitamin D analogues, especially calcitriol, potentiate almost every cytotoxic agent with which combination therapies have been tested.
Author(s): Heide S. Cross (auth.), Donald L. Trump, Candace S. Johnson (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2011
Language: English
Pages: 342
Tags: Cancer Research; Nutrition; Pharmacology/Toxicology
Front Matter....Pages i-xi
Vitamin D: Synthesis and Catabolism – Considerations for Cancer Causation and Therapy....Pages 1-24
The Molecular Cancer Biology of the VDR....Pages 25-52
Anti-inflammatory Activity of Calcitriol in Cancer....Pages 53-71
The Epidemiology of Vitamin D and Cancer Risk....Pages 73-97
Vitamin D and Angiogenesis....Pages 99-114
Vitamin D: Cardiovascular Function and Disease....Pages 115-142
Induction of Differentiation in Cancer Cells by Vitamin D: Recognition and Mechanisms....Pages 143-174
Vitamin D and Cancer Chemoprevention....Pages 175-189
Molecular Biology of Vitamin D Metabolism and Skin Cancer....Pages 191-219
Vitamin D and Prostate Cancer....Pages 221-249
Vitamin D and Hematologic Malignancies....Pages 251-278
The Vitamin D Signaling Pathway in Mammary Gland and Breast Cancer....Pages 279-293
Vitamin D and Colorectal Cancer....Pages 295-313
Unique Features of the Enzyme Kinetics for the Vitamin D System, and the Implications for Cancer Prevention and Therapeutics....Pages 315-326
Assessment of Vitamin D Status in the 21 st Century....Pages 327-338
Back Matter....Pages 339-342
