Currently, there is no single source that permits comparison of the factors, elements, enzymes and/or mechanisms employed by different classes of viruses for genome replication. As a result, we (and our students) often restrict our focus to our particular system, missing out on the opportunity to define unifying themes in viral genome replication or benefit from the advances in other systems. For example, extraordinary biological and experimental paradigms that have been established over the past five years for the DNA replication systems of bacteriophage T4 and T7 will likely be of great value to anyone interested in studying a replisome from any virus. These studies could easily go unnoticed by animal RNA and DNA virologists. It is our hope that this monograph will cross-fertilize and invigorate the field, as well as encourage students into this area of research.
Author(s): Aniko V. Paul, George A. Belov, Ellie Ehrenfeld, Eckard Wimmer (auth.), Kevin D. Raney, Matthias Gotte, Craig E. Cameron (eds.)
Edition: 1
Publisher: Springer US
Year: 2009
Language: English
Pages: 636
Tags: Virology; Microbiology; Immunology; Cell Biology; Biochemistry, general; Human Genetics
Front Matter....Pages i-xvii
Front Matter....Pages 1-1
Model of Picornavirus RNA Replication....Pages 3-23
Coronavirus Genome Replication....Pages 25-39
Flaviviruses....Pages 41-60
Hepatitis C Virus Genome Replication....Pages 61-88
Brome Mosaic Virus RNA Replication and Transcription....Pages 89-108
Retroviruses....Pages 109-128
Hepadnaviral Genomic Replication....Pages 129-143
Rhabdoviruses....Pages 145-162
Orthomyxovirus Genome Transcription and Replication....Pages 163-180
Arenaviruses: Genome Replication Strategies....Pages 181-200
Core-Associated Genome Replication Mechanisms of dsRNA Viruses....Pages 201-224
Poxviruses....Pages 225-247
Herpesvirus Genome Replication....Pages 249-265
Host Factors Promoting Viral RNA Replication....Pages 267-295
Host Factors that Restrict Retrovirus Replication....Pages 297-334
Front Matter....Pages 1-1
T4 Phage Replisome....Pages 337-364
Atomic Structure of the Herpes Simplex Virus 1 DNA Polymerase....Pages 365-381
RNA Virus Polymerases....Pages 383-401
Human Immunodeficiency Virus Reverse Transcriptase....Pages 403-427
Viral Helicases....Pages 429-466
Front Matter....Pages 1-1
Integrase: Structure, Function, and Mechanism....Pages 467-478
Front Matter....Pages 479-479
Viral DNA Polymerase Inhibitors....Pages 481-526
Viral RNA Polymerase Inhibitors....Pages 527-548
HIV-1 Reverse Transcriptase Inhibitors and Mechanisms of Resistance....Pages 549-570
Lethal Mutagenesis....Pages 571-587
Clinical Implications of Reverse Transcriptase Inhibitor Resistance....Pages 589-619
Back Matter....Pages 621-636
