Variation in the Human Genome (Novartis Foundation Symposia)

VARIATION IN THE HUMAN GENOME......Page 5
Contents......Page 7
Participants......Page 9
lntroduction......Page 13
Phylogeographic variability in traditional societies......Page 18
Interpreting genetic variabiIity: the effects of shared evolutionary history......Page 37
Microsatellites: evolution and mutational processes......Page 63
The phenylalanine hydroxylase locus: a marker for the history of phenylketonuria and human genetic diversity......Page 85
Genetic and geographical variability in cystic fibrosis: evolutionary considerations......Page 109
Unusual inheritance patterns due to dynamic mutation in fragile X syndrome......Page 131
Control of b-thalassaemia by carrier screening, genetic counselling and prenatal diagnosis: the Sardinian experience......Page 149
Multigenic control of skin tumour development in mice1......Page 168
Population genetics of tumours......Page 193
Genetic factors that contribute to interindividual variations in plasma low density lipoprotein-cholesterol levels1......Page 206
Genetic architecture of common mu Itifactorial diseases......Page 223
World distribution of HLA alleles and implications for disease......Page 245
Cladistic approaches to identifying determinants of variability in multifactorial phenotypes and tt e evolutionary significance of var ation in the human genome......Page 271
Quantitative phenotype analysis for localization and identification of disease-related genes in a complex genetic background......Page 296
The genetics of common diseases: the implications of population variability......Page 312
Final discussion......Page 324
Summary......Page 327
Index of contributors......Page 330
Subject index......Page 332