This book contains the papers which were presented at the First Gulf Shores Symposium on Unusual DNA Structures. The meeting was held April 6-8, 1987, in Gulf Shores, Alabama. Averitable explosion has taken place in recent years regarding our understanding of unusual DNA structures. This symposium was dedicated to enhancing our understanding of the biology and chemistry of these important structural features. The symposium was supported by funds provided by the Department of Biochemistry, University of Alabama at Birmingham, Schools of Medicine and Dentistry. We wish to express our app~eciationto Ms. Patti Guyton for her expert organizational skills and assistance in organizing the meeting and preparation of this book. Robert D. Wells and Stephen C. Harvey Department of Biochemistry Schools of Medicine and Dentistry University of Alabama at Birmingham Birmingham, Alabama 35294 VII VIII ;;C' Pete Dickie 1. Dave Wilson 20. 39. Paul Hagerman 58. Robert Shapiro 2. Wang-Ting Hsieh David Pettijohn 21. 40. Jacquelynn Larson 59. Angel Garcia 3. Hark Glover Hicaela Caserta 22. 41. Johanna Griffin 60. Richard Lavery 4. David Pulleyblank 23. Adam Jaworski 42. Jeremy Lee 61. Norma Wills 5. Robert Wells 24. Han Htun 43.
Author(s): Robert D. Wells, Sorour Amirhaeri, John A. Blaho (auth.), Robert D. Wells, Stephen C. Harvey (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 1988
Language: English
Pages: 311
Tags: Biochemistry, general
Front Matter....Pages i-xvi
Unusual DNA Structures and the Probes Used for their Detection....Pages 1-21
The Specificity of “Single Strand Specific Endonucleases”: Probes of phosphodiester conformation in double stranded nucleic acids. Left-Handed Polypurine/polypyrimidine structures. Long range transmission of conformational information in DNA.....Pages 23-44
Chromatin Structure and DNA Structure at the hsp 26 Locus of Drosophila ....Pages 45-53
Cruciform Extrusion in Supercoiled DNA — Mechanisms and Contextual Influence....Pages 55-72
Torsional Stress, Unusual DNA Structures, and Eukaryotic Gene Expression....Pages 73-89
Development of a Model for DNA Supercoiling....Pages 91-101
Cruciform Transitions Assayed Using a Psoralen Crosslinking Method: Applications to measurements of DNA torsional tension....Pages 103-114
NMR-Distance Geometry Studies of Helical Errors and Sequence Dependent Conformations of DNA in Solution....Pages 115-161
Hyperreactivity of the B-Z Junctions Probed by Two Aromatic Chemical Carcinogens, 2-N,N-Acetoxyacetylaminofluorene and 3-N,N-Acetoxyacetyl-Amino-4,6-Dimethyldipyrido[1,2-a:3′,2′-d] Imidazole....Pages 163-171
Inherently Curved DNA and its Structural Elements....Pages 173-187
DNA Flexibility Under Control: The Jumna Algorithm and its Application to BZ Junctions....Pages 189-206
Base Sequence Effects in Curved and Rodlike DNA....Pages 207-224
Sequence-Dependent Curvature of DNA....Pages 225-236
Biophysical Principles of Specificity and Stability of Protein-DNA Interactions: Application to RNA Polymerase (Eσ 70 )-Promoter Interactions....Pages 237-251
Immunochemical Approaches to the Definition of Unusual Nucleic Acid Structures....Pages 253-265
Molecular Mechanical Studies on the B → Z Energetics of DNA Sequences....Pages 267-285
Usual and Unusual DNA Structures: A Summing-Up....Pages 287-306
Back Matter....Pages 307-311
