Diabetes is now a major global health problem. About 123 million people have diabetes, approximately 2.10f the worlds population. Of these 120 million have type 2 diabetes. There is a range of reasons for the explosion in prevalence of type 2 diabetes, from changes in lifestyle and environmental factors to complex effects on genetic susceptibility. Type 2 Diabetes: Prediction and Prevention describes the progress made on predicting diabetes through better understanding of the genetics of the disease and the intrauterine environment, and the strategies for prevention. It is an essential text for all with an interest in the disease. Subjects covered include:The genetics of type 2 diabetesInsulin resistance - the evidence for a genetic componentIntrauterine development and diabetesScreening and preventionObesityDrug treatmentGenetic counselling and ethicsType 2 diabetes is a disease of the modern world and it needs to be combated through modern science. This comprehensive book will inform all those who work in the field of diabetes, whether researchers or practitioners, on what is known about the disease and on current and future strategies to manage the disease at both individual patient and population levels.
Author(s): Graham A. Hitman
Edition: 1
Publisher: Wiley
Year: 1999
Language: English
Pages: 412
Contents......Page 4
Preface......Page 6
Contributors......Page 8
Part A Introduction......Page 10
1 Aetiology......Page 12
2 Diagnosis: The Scale of the Problem and Future Risks......Page 26
Part B Genetics......Page 46
3 An Introduction to the Genetics of Type 2 Diabetes......Page 48
4 Methods to Identify the Major Gene......Page 70
5 Insulin Resistance: The Evidence for a Genetic Component......Page 94
6 Maturity-onset Diabetes of the Young: A Monogenic Model of Diabetes......Page 116
7 Relevance of Animal Models to Humans......Page 136
Part C Other Factors Relevant to Prediction......Page 150
8 Non-genetic Transmission......Page 152
9 Intrauterine Development and its Relationship to Type 2 Diabetes Mellitus......Page 162
10 Lessons from Gestational Diabetes......Page 178
11 Obesity......Page 202
Part D Prevention......Page 218
12 Primary Prevention of Non-communicable Diseases......Page 220
13 Screening and Prevention of Type 2 Diabetes......Page 248
14 Dietary Risk Factors......Page 266
15 Prevention Strategies: Diet and Exercise......Page 282
16 Prevention Strategies: The Use of Drugs......Page 292
17 Non-diabetic Relatives: Characteristics and Opportunities for Intervention......Page 312
Part E Future Developement......Page 332
18 Problems Specific to Developing Countries and the Effects of Westernization......Page 334
19 Genetic Counselling and Ethical Aspects......Page 358
20 Gene Therapy for Type 2 Diabetes: Will it have a Role?......Page 378
21 Costs and Profits of Prevention......Page 392
C......Page 406
G......Page 407
I......Page 408
N......Page 409
R......Page 410
Z......Page 411
