Tumor Angiogenesis and Microcirculation (Basic and Clinical Oncology)

Compiling the latest developments in anticancer therapies based on the connection between tumor and capillary growth, Tumor Angiogenesis and Microcirculation presents a comprehensive overview of diverse aspects of angiogenesis-related cancer research. Highlights the role angiogenesis and its inhibitors play in the growth, metastasis, and dormancy of tumors! Facilitating the progress of clinical practice with insights from methodological and scientific results, Tumor Angiogenesis and Microcirculation ·summarizes biological principles of angiogenesis and microcirculation, from endothelial cells and pericytes, and extracellular matrix regulation to matrix metalloproteinases (MMPs) and plasmin and plasmin inhibitors ·examines proangiogenic factors such as vascular endothelial (VEGF) and basic fibroblast (bFGF) growth factors, tie receptors, and cytokines ·outlines methods for discovering angiogenesis stimulators and inhibitor peptides, particularly the clinical development of thrombospondin, angiostatin, endostatin, and MMP inhibitors ·reveals the link between oncogenes and neoplastic angiogenesis and its regulation by the organ microenvironment ·investigates tumor vascularity in relation to tumor growth and the spread of cancer ·details promising future applications, including perspectives in vascular cancer therapy ·and more! Combining the resources of 60 recognized experts and nearly 3000 pertinent literature references, drawings, photographs, and x-rays, Tumor Angiogenesis and Microcirculation profits oncologists, pathologists, hematologists, and radiation and hemato-oncologists; surgeons and internists; cardiologists; immunologists; cell, molecular, and developmental biologists; rheumatologists; ophthalmologists; dermatologists; and medical school students in these disciplines.