Univ. Medical Center Utrecht, The Netherlands. Provides readers with a well-balanced overview of the current biological principles of angiogenesis and microcirculation and its relationship to tumor growth. Outlines methods for finding ways to inhibit circulation to tumors as a method of treatment, including recent achievements.
Author(s): Emile E. Voest, Patricia A. D'Amore
Series: Basic and Clinical Oncology
Edition: 1
Publisher: Informa Healthcare
Year: 2001
Language: English
Pages: 640
Contents......Page 8
Series Introduction......Page 4
Preface......Page 6
Contributors......Page 12
1 Endothelial Cells and Pericytes in Tumor Vasculature......Page 18
2 The Extracellular Matrix and the Regulation of Angiogenesis......Page 26
3 Matrix Metalloproteinases (Matrixins) and Their Inhibitors (TIMPS) in Angiogenesis......Page 46
4 Regulation of Cell Migration in the Process of Angiogenesis......Page 76
5 Plasmin, Plasmin Inhibitors, and Angiogenesis......Page 90
6 Assays to Study Angiogenesis......Page 108
7 Screening for Angiogenesis Inhibitors with the Chick Chorioallantoic Membrane and the Mouse Corneal Micropocket......Page 120
8 Capillary Morphogenesis In Vitro: Cytokine Interactions and Balanced Proteolysis......Page 128
9 Skin Fold Chamber Models......Page 160
10 Protease Assays and Their Use in the Discovery of Novel Regulators of Angiogenesis......Page 172
11 Vascular Endothelial Growth Factor/Vascular Permeability Factor: Multiple Biological Activities for Promoting Angiogenesis......Page 184
12 Tie Receptors, Ang Ligands......Page 202
13 Vascular Endothelial Growth Factor Receptors......Page 216
14 Regulation of Vascular Endothelial Growth Factor (VEGF) Expression......Page 230
15 Fibroblast Growth Factors......Page 244
16 Role of Proangiogenic Cytokines and Inhibitors of Neovascularization in Tumor Angiogenesis......Page 282
17 The Link Between Oncogenes, Signal Transduction Therapy, and Tumor Angiogenesis......Page 302
18 Genetic Control of Angiogenesis by Tumor Suppressor Genes......Page 324
19 Regulation of Neoplastic Angiogenesis by the Organ Microenvironment......Page 338
20 Role of Macrophages in Tumor Angiogenesis......Page 352
21 Phenotypic Analysis of Endothelium from the Tumor Vasculature......Page 366
22 Drug Delivery and Angiogenesis Inhibition in the Treatment of Brain Tumors......Page 378
23 Matrix-Associated Endogenous Inhibitors of Angiogenesis......Page 392
24 αvβ3 and Its Antagonists in the Control of Angiogenesis......Page 404
25 The Role of Vascular Endothelial Growth Factor in Angiogenesis......Page 416
26 TNP-470: Preclinical and Clinical Development......Page 448
27 Matrix Metalloproteinase Inhibitors......Page 466
28 Tumoral Vascularity: What Does It Tell Us About the Growth and Spread of Cancer?......Page 482
29 The Prognostic and Diagnostic Value of Circulating Angiogenic Factors in Cancer Patients......Page 504
30 Perspectives in Vascular Cancer Therapy: An Introduction......Page 518
31 The Combination of Antiangiogenic Therapy with Cytotoxic Therapy: A Systems Approach......Page 524
32 Targeting the Vasculature of Solid Tumors......Page 566
33 Combining Antivascular Approaches with Radiotherapy: A Perspective......Page 596
34 Antiangiogenic Gene Therapy......Page 614
A......Page 626
B......Page 627
C......Page 628
E......Page 629
H......Page 630
I......Page 631
N......Page 632
P......Page 633
S......Page 635
T......Page 636
V......Page 637
Z......Page 638
