The Symposium on "Transport through Membranes : Carriers. Channels and Pumps" Inaugurates the third decade of the Jerusalem Symposia. It enlarges substantially their conceptual scope by Introducing a new subject not treated there previously. In fact. It Is a topic particularly well suited for the general object of these International meetings which Is to reassemble In an exhaustive Interdisciplinary discussion chemists. physicists and biologists. theoreticians and experimentalists. The main theme of the Symposium was the presentation and evaluation of the most up-to-date data on the structural and dynamic aspects of transport through membranes within the three main pathways: through carriers. channels and pumps. This goal was fully achieved thanks to the participation of a most outstanding assembly of world's experts In the field. We wish to thank Madame Pullman. the real organizer and mainspring of this meeting. for having composed a most exciting and excellent program and for carrying It out successfully. As the twenty preceding ones this Symposium was held under the auspices of the Israel Academy of Sciences and Humanities and the Hebrew University of Jerusalem. It was sponsored by the Instltut de Blologle Physlco Chimique. Fondatlon Edmond de Rothschild of Paris. We wish to express once again our gratitude to the Baron Edmond de Rothschild for his constant and generous support which makes this continuous endeavour possible.
Author(s): G. Wipff, J. M. Wurtz (auth.), Alberte Pullman, Joshua Jortner, Bernard Pullman (eds.)
Series: The Jerusalem Symposia on Quantum Chemistry and Biochemistry 21
Edition: 1
Publisher: Springer Netherlands
Year: 1988
Language: English
Pages: 570
Tags: Biochemistry, general; Physical Chemistry
Front Matter....Pages i-ix
Dynamic Views of Macrocyclic Receptors: Molecular Dynamics Simulations and Normal Modes Analysis....Pages 1-26
Ion Selectivity and Molecular Structure of Binding Sites and Channels in Icosahedral Viruses....Pages 27-50
The molecular packing of porin, a trimeric membrane protein in tetragonal crystal form....Pages 51-55
Helical Structures; Artificial Solutions for Ion Transport....Pages 57-66
Modulation of Ionophore Properties by Chemical Modifications of Synthetic Alamethicin Analogues....Pages 67-76
Mutagenesis of the Cooh-Terminal Channel Domain of Colicin E1 Affecting the Ion Selectivity of the Channel....Pages 77-89
The Structure and Dynamics of Membrane Spanning Helices by High Resolution NMR and Molecular Dynamics....Pages 91-101
The Gramicidin Pore: Crystal Structure of a Gramicidin/Cesium Chloride Complex....Pages 103-113
Do Amino Acid Substitutions Alter the Structure of Gramicidin Channels? Chemistry at the Single Molecule Level....Pages 115-132
How do Amino Acid Substitutions Alter the Function of Gramicidin Channels?....Pages 133-145
Linear Gramicidins : Influence of the Nature of the Aromatic Side Chains of the Channel Conductance....Pages 147-165
The Gramicidin a Channel: Left Versus Right-Handed Helix....Pages 167-185
Guanidinium as a Probe of the Gramicidin Channel Interior....Pages 187-201
Thermodynamics of Cation Binding and Transport by Gramidicin....Pages 203-218
Structure and Dynamics of Water on Membrane Surfaces and in Narrow Transmembrane Channels....Pages 219-235
A Molecular Dynamics Study of Cesium Ion Motion in a Gramicidin-Like Channel. Structural and Energetic Implications....Pages 237-251
Radiolysis and Photolysis of Ion Channels Formed by Gramicidin A....Pages 253-265
Influence of Gramicidin on Lipid Organization and Dynamics in Membranes....Pages 267-287
Side Chain and Backbone Conformation of Gramicidin a in Lipid Bilayer Membranes....Pages 289-295
Ionic Permeability and the Open Channel Structure of the Nicotinic Acetylcholine Receptor....Pages 297-319
Functional Organization of the Acetylcholine Receptor: A Model of Ligand Gated Ion Channel....Pages 321-335
Theoritical Study of Potential Ion-Chanels Formed by Bundles of α-Helices. Partial Modelling of the Acetylcholine Receptor Channel....Pages 337-357
Properties and Problems of the Helix-M2 model of the Acetylcholine Receptor-Ion Channel.....Pages 359-367
Structural Models for Membrane Insertion and Channel Formation by Antiparallel Alpha Helical Membrane Peptides....Pages 369-379
Bacteriorhodopsin in and out of Shape: Experimental Evidence in Favor of a Two-Stage Mechanism for Integral Membrane Protein Folding....Pages 381-398
Observation of “N” in the Photocycle of Bacteriorhodopsin: A Satisfactory Confirmation of Theoretical Predictions....Pages 399-408
Hydrogen - Bonded Systems as Proton Wires Formed by Side Chains of Proteins and by Side Chains and Phosphates.....Pages 409-420
Characterization of Halorhodopsin reconstituted in asolectin liposomes....Pages 421-428
Mechanism of Chloride Transport by Halorhodopsin....Pages 429-440
Mechanism of Anion Transport Through the Phosphate-Starvation-Inducible Outer Membrane Protein P of Pseudomonas Aeruginosa....Pages 441-454
Charge Translocation in a Single Turnover of the Na,K-pump....Pages 455-469
Carrier Kinetics Show how the Sodium Pump Uses ATP to Render Pumping of both Na and K Effective, and Suggests a Model for the ATP Synthetases....Pages 471-481
Single-Channel and Oligo-Channel Recordings: Thermodynamic Information Obtainable from Electric Fluctuations Produced by a Small Number of Ionic Channels....Pages 483-505
The Crystal structure of the Photosynthetic Reaction Center from Rhodopseudomonas Viridis....Pages 507-512
Molecular Dynamics Simulation of the Primary Processes in the Photosynthetic Reaction Center of Rhodopseudomonas Viridis ....Pages 513-525
Pump and Displacement Currents of Reconstituted ATP Synthase on Black Lipid Membranes....Pages 527-544
Ion-Binding Properties of NonHomogenous Biological Membrane Structures....Pages 545-562
Back Matter....Pages 563-570
