Transdermal Drug Delivery: Concepts and Application provides comprehensive background knowledge and documents the most recent advances made in the field of transdermal drug delivery. It provides comprehensive and updated information regarding most technologies and formulation strategies used for transdermal drug delivery. There has been recent growth in the number of research articles, reviews, and other types of publications in the field of transdermal drug delivery. Research in this area is active both in the academic and industry settings. Ironically, only about 40 transdermal products with distinct active pharmaceutical ingredients are in the market indicating that more needs to be done to chronicle recent advances made in this area and to elucidate the mechanisms involved. This book will be helpful to researchers in the pharmaceutical and biotechnological industries as well as academics and graduate students working in the field of transdermal drug delivery and professionals working in the field of regulatory affairs focusing on topical and transdermal drug delivery systems. Researchers in the cosmetic and cosmeceutical industries, as well as those in chemical and biological engineering, will also find this book useful.
Author(s): Kevin Ita
Publisher: Academic Press
Year: 2020
Language: English
Pages: 324
City: New York
Transdermal Drug Delivery
Copyright
Dedication
Contents
List of figures
List of tables
Preface
Acknowledgment
1 Transcutaneous drug administration
Passive transdermal therapeutic systems
References
2 Anatomy of the human skin
References
3 Basic principles of transdermal drug delivery
Transdermal drug delivery experiments
Selection of transdermal drug delivery candidates
Physico-chemical determinants of percutaneous penetration
Molecular weight
Partition coefficient
Solubility
Diffusion coefficient
Ionization
Biological factors and transdermal drug delivery
Age
Hydration
References
4 Elastic liposomes and other vesicles
Alpha-tocopherol
Insulin
Sodium stibogluconate
Minoxidil and caffeine
Asenapine
Gap junction protein
Tetanus toxoid
Ondansetron
Surfactant-based elastic vesicles
Niosomes
Ethosomes
Cucurmin
Ovalbumin
Griseofulvin
Terbinafine
Transethosomes
References
5 Chemical permeation enhancers
Terpenes
Water
Azone
Pyrrolidone and derivatives
Alcohols
Esters
Dimethyl sulfoxide
Fatty acids
Glycol ethers
Surfactants
Peptides
Amino acid derivatives
Ceramide-like penetration enhancers
Oleodendrimers
Ionic liquids and deep eutectic solvents
References
6 Microemulsions
Transdermal delivery of indomethacin with microemulsion
Percutaneous transport of α-santalol through breast skin and mammary papilla
Skin delivery of propranolol-loaded microemulsions
The Influence of microemulsion on the percutaneous transport of tetramethylpyrazine
The influence of microemulsion on the transcutaneous delivery of testosterone
Transdermal microemulsion loaded with methyl dihydrojasmonate
The effect of microemulsion on the transcutaneous permeation of dencichine
Skin delivery of clotrimazole-loaded microemulsions
Skin delivery of the tetrapeptide PKEK with microemulsions
Microemulsion for the skin delivery of bee-venom phospholipase A2 (Api m 1)
Transcutaneous delivery of metronidazole with microemulsion
Repaglinide microemulsion gel for percutaneous transport
The influence of microemulsion on the transcutaneous delivery of cyclosporine
Transcutaneous delivery of lapachol with microemulsion
Microemulsion for the skin transport of zidovudine
Percutaneous transport of ropivacaine-loaded microemulsion
Celecoxib microemulsion-based gel for transdermal delivery
Skin delivery of imiquimod with microemulsion
References
7 Prodrugs
Skin delivery of siRNA with prodrugs
Skin transport of bioengineered carboxymethyl cellulose-doxorubicin prodrugs
The effect of ester promoieties on the percutaneous transport of ketorolac
Percutaneous penetration of apomorphine prodrugs
Skin delivery of polymer conjugated prodrug of all-trans retinoic acid
Skin delivery of naproxen prodrugs
Transdermal delivery of natrexone prodrugs
Transcutaneous permeation of haloperidol prodrugs
Skin delivery of fexofenadine prodrugs
Prodrugs of phenolic compounds
Polyoxyethylene esters as prodrugs of selected nonsteroidal antiinflammatory drugs for transdermal delivery
Transdermal delivery of phenylalanyl-glycine prodrugs
Skin permeation of atenolol and propranolol esters
The transcutaneous penetration of theophylline prodrugs
Transdermal delivery of acyclic nucleoside phosphonates
Percutaneous transport of thalidomide prodrugs
Transdermal delivery of cytarabine prodrugs
Transdermal permeation of acetylsalicylic acid prodrugs
References
8 Microneedles
Solid microneedles
Fabrication
Transdermal drug delivery with solid microneedles
Dissolving microneedles
Hollow microneedles
Coated microneedles
Dip coating
Electrohydrodynamic atomization
Inkjet printing
Three-dimensional printing
Spray coating
Partial immersion
Nitrogen gas jet coating
Polyelectrolyte multilayer assembly
Hydrogel-forming microneedles
References
9 Iontophoresis, magnetophoresis, and electroporation
Transdermal iontophoretic delivery of therapeutic agents
Ranitidine
Methotrexate
Penbutolol sulfate
Almotriptan malate
3-Fluoroamphetamine
Acyclovir
Granisetron
Memantine
Ketoprofen
Dexamethasone
Donepezil
3-Fluoroamphetamine
Magnetophoresis
WARNING!!! DUMMY ENTRY
ETP
ETP-mediated transdermal delivery of doxepin
Using ETP to transport calcein
Delivering fentanyl across the human skin with ETP
Percutaneous transport of metoprolol with ETP
ETP-mediated transdermal delivery of nalbuphine
The effect of ETP on the transdermal permeation of doxorubicin
Delivery of iron with ETP
ETP-mediated transdermal delivery of Kb-binding ovalbumin-peptide SIINFEKL
Transcutaneous transport of neostigmine via ETP
Skin delivery of sinomenine hydrochloride by ETP
Skin delivery of methotrexate via ETP
Percutaneous transport of tetracaine via ETP
ETP-mediated transcutaneous permeation of alniditan
ETP-assisted skin permeation of heparin
Transdermal delivery of domperidone via ETP
ETP-mediated transdermal penetration of diphtheria toxoid
Percutaneous transport of insulin via ETP
ETP-mediated percutaneous delivery of andrographolide
The effect of ETP on the percutaneous absorption of genistein
ETP-assisted skin transport of insulin
The influence of ETP on the transcutaneous penetration of terazosin
ETP-mediated delivery of vaccines against Trypanosoma cruzi
ETP-mediated skin delivery of pDNA vaccine that codes for the influenza nucleoprotein (PR8)
References
10 Sonophoresis
Mechanism of transdermal sonophoresis
Acoustic streaming
Cavitation
Rectified diffusion
Cellular-level effect
Thermal effect
Transdermal sonophoretic delivery of therapeutic agents
Methotrexate
Gemcitabine
Sinomenine
Penbutolol
Propranolol
Ketoprofen
Diclofenac
Galantamine
Rivastigmine
Lercanidipine hydrochloride
Insulin
Heparin
Histamine
Caffeine
References
11 Laser and other ablation technologies
Heat
References
12 Mathematical modeling of transdermal drug delivery
Artificial neural network
Macroscopic models
References
Index
