Publisher: U.S. Public Health Service
Year: 0
Language: English
Pages: 132
TOXICOLOGICAL PROFILE FOR N-NITROSODIMETHYLAMINE......Page 1
DISCLAIMER......Page 2
FOREWORD......Page 3
CONTENTS......Page 5
LIST OF FIGURES......Page 9
LIST OF TABLES......Page 11
1.2 HOW MIGHT I BE EXPOSED TO N-NITROSODIMETHYLAMINE?......Page 13
1.4 HOW CAN N-NITROSODIMETHYUMINE AFFECT MY HEALTH?......Page 14
1.8 WHERE CAN I GET MORE INFORMATION?......Page 15
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 21
2.2.1.1 Death......Page 22
2.2.1.2 Systemic Effects......Page 25
2.2.1.6 Reproductive Effects......Page 26
2.2.1..8 Cancer......Page 27
2.2.2.1 Death......Page 28
2.2.2.2 Systemic Effects......Page 41
2.2.2.3 Immunological Effects......Page 45
2.2.2.5 Developmental Effects......Page 46
2.2.2.7 Genotoxic Effects......Page 47
2.2.2.8 Cancer......Page 48
2.2.3.2 Systemic Effects......Page 50
2.3 RELEVANCE TO PUBLIC HEALTH......Page 51
2.4 LEVELS IN HUMAN TISSUES AND FLUIDS ASSOCIATED WITH HEALTH EFFECTS......Page 58
2.6.1.2 Oral Exposure......Page 59
2.6.2.2 Oral Exposure......Page 60
2.6.3.2 Oral Exposure......Page 61
2.7 INTERACTIONS WITH OTHER CHEMICALS......Page 63
2.9 ADEQUACY OF THE DATABASE......Page 64
2.9.2 Data Needs......Page 65
2.9.3 On-going Studies......Page 70
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 71
4.4 DISPOSAL......Page 75
4.5.1 Data Needs......Page 76
5.1 OVERVIEW......Page 77
5.2.2 Water......Page 78
5.3.1 Transport and Partitioning......Page 79
5.3.2.3 Soil......Page 80
5.4.2 Water......Page 81
5.4.4 Other Media......Page 82
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 85
5.7 ADEQUACY OF THE DATABASE......Page 86
5.7.1 Data Needs......Page 87
5.7.2 On-going Studies......Page 88
6.2 ENVIRONMENTAL SAMPLES......Page 89
6.3.1 Data Needs......Page 93
6.3.2 On-going Studies......Page 94
7. REGULATIONS AND ADVISORIES......Page 95
8. REFERENCES......Page 99
EPA Health Advisory......Page 127
Minimal Risk Level......Page 128
Reproductive Toxicity......Page 129
Uncertainty Factor (UF)......Page 130
APPENDIX: PEER REVIEW......Page 131
