Publisher: U.S. Public Health Service
Year: 0
Language: English
Pages: 118
TOXICOLOGICAL PROFILE FOR ISOPHORONE......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 8
LIST OF TABLES......Page 9
1.4 HOW CAN ISOPHORONE AFFECT MY HEALTH?......Page 10
1.6 WHAT LEVELS OF EXPOSURE HAVE RESULTED IN HARMFUL HEALTH EFFECTS?......Page 11
2.1 INTRODUCTION......Page 19
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 20
2.2.1.1 Death......Page 21
2.2.1.2 Systemic Effects......Page 26
2.2.1.4 Neurological Effects......Page 30
2.2.1.5 Developmental Effects......Page 31
2.2.2.1 Death......Page 32
2.2.2.2 Systemic Effects......Page 40
2.2.2.4 Neurological Effects......Page 42
2.2.2.8 Cancer......Page 43
2.2.3.1 Death......Page 44
2.2.3.6 Reproductive Effects......Page 47
2.3 RELEVANCE TO PUBLIC HEALTH......Page 48
2.6.1.2 Oral Exposure......Page 55
2.6.2.3 Dermal Exposure......Page 56
2.7 INTERACTIONS WITH OTHER CHEMICALS......Page 57
2.9.1 Existing Information on Health Effects of Isophorone......Page 59
2.9.2 Data Needs......Page 61
3.1 CHEMICAL IDENTITY......Page 65
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 66
4.3 USE......Page 69
5.1 OVERVIEW......Page 70
5.2.2 Water......Page 71
5.3.1 Transport and Partitioning......Page 72
5.3.2.2 Water......Page 73
5.4.1 Air......Page 74
5.4.2 Water......Page 75
5.4.4 Other Media......Page 82
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 83
5.7 ADEQUACY OF THE DATABASE......Page 86
5.7.2 On-going Studies......Page 89
6.2 ENVIRONMENTAL SAMPLES......Page 90
6.3.2 On-going Studies......Page 93
7. REGULATIONS AND ADVISORIES......Page 94
8. REFERENCES......Page 98
Developmental Toxicity......Page 106
Minimal Risk Level......Page 107
Teratogen......Page 108
User’s Guide......Page 109
Acronyms, Abbreviations, and Symbols......Page 114
Peer Review......Page 118
