Toxicological profiles - Diazinon

TOXICOLOGICAL PROFILE FOR DIAZINON......Page 1
CONTENTS......Page 8
DISCLAIMER......Page 2
UPDATE STATEMENT......Page 3
FOREWORD......Page 4
CONTRIBUTORS......Page 6
PEER REVIEW......Page 7
LIST OF FIGURES......Page 11
LIST OF TABLES......Page 12
1.1 WHAT IS DIAZINON?......Page 13
1.2 WHAT HAPPENS TO DIAZINON WHEN IT ENTERS THE ENVIRONMENT?......Page 14
1.4 HOW CAN DIAZINON ENTER AND LEAVE MY BODY?......Page 15
1.5 HOW CAN DIAZINON AFFECT MY HEALTH?......Page 16
1.7 WHAT RECOMMENDATIONS HAS THE FEDERAL GOVERNMENT MADE TO PROTECT HUMAN HEALTH?......Page 17
1.8 WHERE CAN I GET MORE INFORMATION?......Page 18
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 19
2.2.1.2 Systemic Effects......Page 21
2.2.1.4 Neurological Effects......Page 27
2.2.1.5 Reproductive Effects......Page 29
2.2.1.8 Cancer......Page 30
2.2.2.1 Death......Page 31
2.2.2.2 Systemic Effects......Page 34
2.2.2.3 Immunological and Lymphoreticular Effects......Page 66
2.2.2.4 Neurological Effects......Page 67
2.2.2.5 Reproductive Effects......Page 74
2.2.2.6 Developmental Effects......Page 75
2.2.2.8 Cancer......Page 78
2.2.3.1 Death......Page 79
2.2.3.2 Systemic Effects......Page 80
2.2.3.3 Immunological and Lymphoreticular Effects......Page 84
2.2.3.6 Developmental Effects......Page 85
2.2.3.8 Cancer......Page 86
2.3.1.3 Dermal Exposure......Page 87
2.3.2.4 Other Exposure......Page 88
2.3.3.4 Other Exposure......Page 89
2.3.4.2 Oral Exposure......Page 90
2.4 MECHANISMS OF ACTION......Page 92
2.5 RELEVANCE TO PUBLIC HEALTH......Page 93
2.6 BIOMARKERS OF EXPOSURE AND EFFECT......Page 104
2.6.2 Biomarkers Used to Characterize Effects Caused by Diazinon......Page 106
2.7 INTERACTIONS WITH OTHER CHEMICALS......Page 107
2.8 POPULATIONS THAT ARE UNUSUALLY SUSCEPTIBLE......Page 108
2.9.2 Reducing Body Burden......Page 110
2.9.3 Interfering with the Mechanism of Action for Toxic Effects......Page 111
2.10.1 Existing Information on Health Effects of Diazinon......Page 112
2.10.2 Identification of Data Needs......Page 114
2.10.3 Ongoing Studies......Page 123
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 124
4.2 IMPORT/EXPORT......Page 127
4.3 USE......Page 128
4.4 DISPOSAL......Page 129
5.1 OVERVIEW......Page 131
5.2.2 Water......Page 134
5.3.1 Transport and Partitioning......Page 136
5.3.2.1 Air......Page 140
5.3.2.2 Water......Page 141
5.3.2.3 Soil Transformation and Degradation......Page 142
5.4.1 Air......Page 145
5.4.2 Water......Page 148
5.4.3 Sediment and Soil......Page 151
5.4.4 Other Environmental Media......Page 152
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 153
5.7 ADEQUACY OF THE DATABASE......Page 156
5.7.1 Identification of Data Needs......Page 157
5.7.2 Ongoing Studies......Page 159
6.1 BIOLOGICAL SAMPLES......Page 162
6.2 ENVIRONMENTAL SAMPLES......Page 174
6.3 ADEQUACY OF THE DATABASE......Page 178
6.3.1 Identification of Data Needs......Page 179
6.3.2 Ongoing Studies......Page 181
7. REGULATIONS AND ADVISORIES......Page 182
8. REFERENCES......Page 187
Intermediate Exposure......Page 210
q1*......Page 211
Uncertainty Factor (UF)......Page 212
ATSDR MINIMAL RISK LEVEL......Page 213
MINIMAL RISK LEVEL (MRL) WORKSHEET......Page 215
USER'S GUIDE......Page 221
ACRONYMS, ABBREVIATIONS, AND SYMBOLS......Page 228