Publisher: U.S. Public Health Service
Year: 0
Language: English
Pages: 77
TOXICOLOGICAL PROFILE FOR BIS(CHLOROMETHYL)ETHER......Page 1
DISCLAIMER......Page 2
FOREWORD......Page 3
CONTENTS......Page 5
LIST OF FIGURES......Page 9
LIST OF TABLES......Page 11
1.3 HOW CAN BIS(CHLOROMETHYL) ETHER ENTER AND LEAVE MY BODY?......Page 13
1.6 WHAT LEVELS OF EXPOSURE HAVE RESULTED IN HARMFUL HEALTH EFFECTS?......Page 14
1.8 WHERE CAN I GET MORE INFORMATION?......Page 19
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 21
2.2.1.1 Death......Page 22
2.2.1.2 Systemic Effects......Page 26
2.2.1.4 Immunological Effects......Page 27
2.2.1.8 Cancer......Page 28
2.2.2.1 Death......Page 30
2.2.3.2 Systemic Effects......Page 32
2.3 RELEVANCE TO PUBLIC HEALTH......Page 33
2.6 TOXICOKINETICS......Page 36
2.9.1 Existing Information on Health Effects of BCME......Page 37
2.9.2 Data Needs......Page 39
2.9.3 Ongoing Studies......Page 42
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 43
4.5 ADEQUACY OF THE DATABASE......Page 47
4.5.1 Data Needs......Page 48
5.3.2.1 Air......Page 49
5.3.2.2 Water......Page 50
5.4.4 Other Media......Page 51
5.7.1 Data Needs......Page 52
5.7.2 Ongoing Studies......Page 53
6.2 ENVIRONMENTAL SAMPLES......Page 55
6.3.1 Data Needs......Page 57
6.3.2 Ongoing Studies......Page 58
7. REGULATIONS AND ADVISORY STANDARDS......Page 59
8. REFERENCES......Page 61
Developmental Toxicity......Page 71
Lethal Dose (LDLO)......Page 72
Permissible Exposure Limit (PEL)......Page 73
Target Organ Toxicity......Page 74
Uncertainty Factor (UF)......Page 75
APPENDIX: PEER REVIEW......Page 77
