Publisher: U.S. Public Health Service
Year: 0
Language: English
Pages: 98
TOXICOLOGICAL PROFILE FOR 2-HEXANONE......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 8
LIST OF TABLES......Page 9
1.2 HOW MIGHT I BE EXPOSED TO 2-HEXANONE?......Page 10
1.4 HOW CAN 2-HEXANONE AFFECT MY HEALTH?......Page 11
2.1 INTRODUCTION......Page 12
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 13
2.2.1.1 Death......Page 14
2.2.1.2 Systemic Effects......Page 20
2.2.1.4 Neurological Effects......Page 21
2.2.1.5 Developmental Effects......Page 24
2.2.2 Oral Exposure......Page 25
2.2.2.2 Systemic Effects......Page 26
2.2.2.4 Neurological Effects......Page 30
2.2.3 Dermal Exposure......Page 31
2.2.3.8 Cancer......Page 32
2.3 TOXICOKINETICS......Page 33
2.3.2.2 Oral Exposure......Page 35
2.3.3 Metabolism......Page 36
2.3.4.2 Oral Exposure......Page 38
2.4 RELEVANCE TO PUBLIC HEALTH......Page 39
2.5.1 Biomarkers Used to Identify and/or Quantify Exposure to 2-Hexanone......Page 43
2.6 INTERACTIONS WITH OTHER CHEMICALS......Page 44
2.8 MITIGATION OF EFFECTS......Page 45
2.9.1 Existing Information on Health Effects of 2-Hexanone......Page 46
2.9.2 Data Needs......Page 48
2.9.3 Ongoing Studies......Page 52
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 53
5.1 OVERVIEW......Page 57
5.2.2 Water......Page 58
5.3.1 Transport and Partitioning......Page 60
5.4.1 Air......Page 61
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 62
5.7.1 Data Needs......Page 63
5.7.2 Ongoing Studies......Page 64
6.1 BIOLOGICAL MATERIALS......Page 65
6.3.1 Data Needs......Page 68
7. REGULATIONS AND ADVISORIES......Page 71
8. REFERENCES......Page 74
Chronic Exposure......Page 86
Malformations......Page 87
Target Organ Toxicity......Page 88
User s Guide......Page 89
Acronyms, Abbreviations, and Symbols......Page 95
Peer Review......Page 98
