Toxicological profiles - 2-butanone

TOXICOLOGICAL PROFILE FOR 2-BUTANONE......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 8
LIST OF TABLES......Page 9
1.1 WHAT IS 2-BUTANONE?......Page 10
1.4 HOW CAN 2-BUTANONE AFFECT MY HEALTH?......Page 11
1.7 WHERE CAN I GET MORE INFORMATION?......Page 12
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 13
2.2.1.1 Death......Page 14
2.2.1.2 Systemic Effects......Page 15
2.2.1.3 Immunological Effects......Page 25
2.2.1.4 Neurological Effects......Page 26
2.2.1.7 Genotoxic Effects......Page 27
2.2.2.2 Systemic Effects......Page 28
2.2.2.4 Neurological Effects......Page 33
2.2.3.2 Systemic Effects......Page 34
2.2.3.3 Immunological Effects......Page 35
2.3.1.1 Inhalation Exposure......Page 38
2.3.2.1 Inhalation Exposure......Page 39
2.3.3 Metabolism......Page 40
2.3.4.1 Inhalation Exposure......Page 41
2.4 RELEVANCE TO PUBLIC HEALTH......Page 42
2.5.1 Biomarkers Used to Identify and/or Quantify Exposure to 2- Butanone......Page 49
2.6 INTERACTIONS WITH OTHER CHEMICALS......Page 50
2.8 MITIGATION OF EFFECTS......Page 54
2.9.1 Existing Information on Health Effects of 2-Butanone......Page 55
2.9.2 Data Needs......Page 57
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 62
4.3 USE......Page 67
5.1 OVERVIEW......Page 72
5.2.1 Air......Page 77
5.2.3 Soil......Page 79
5.3.2.1 Air......Page 80
5.3.2.3 Soil......Page 81
5.4.2 Water......Page 82
5.4.4 Other Environmental Media......Page 83
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 85
5.7.1 Data Needs......Page 86
6.1 BIOLOGICAL MATERIALS......Page 88
6.2 ENVIRONMENTAL SAMPLES......Page 93
6.3.1 Data Needs......Page 94
7. REGULATIONS AND ADVISORIES......Page 95
8. REFERENCES......Page 98
Developmental Toxicity......Page 116
Mutagen......Page 117
Threshold Limit Value (TLV)......Page 118
User s Guide......Page 119
Acronyms, Abbreviations, and Symbols......Page 124
PEER REVIEW......Page 128