Toxicological profiles - 1,2-dichloropropane

TOXICOLOGICAL PROFILE FOR 1,2-DICHLOROPROPANE......Page 1
CONTENTS......Page 5
DISCLAIMER......Page 2
FOREWORD......Page 3
LIST OF FIGURES......Page 8
LIST OF TABLES......Page 9
1.2 HOW MIGHT I BE EXPOSED TO 1,2-DICHLOROPROPANE?......Page 11
1.4 HOW CAN 1,2-DICHLOROPROPANE AFFECT MY HEALTH?......Page 12
1.6 WHAT LEVELS OF EXPOSURE HAVE RESULTED IN HARMFUL HEALTH EFFECTS?......Page 13
1.8 WHERE CAN I GET MORE INFORMATION?......Page 18
2.2 DISCUSSION OF HEALTH EFFECTS BY ROUTE OF EXPOSURE......Page 19
2.2.1.1 Death......Page 20
Respiratory Effects.......Page 31
Hematological Effects.......Page 32
Hepatic Effects.......Page 33
Renal Effects.......Page 34
2.2.1.3 Immunological Effects......Page 35
2.2.1.5 Developmental Effects......Page 36
2.2.2.1 Death......Page 37
Gastrointestinal Effects.......Page 46
Hematological Effects.......Page 47
Hepatic Effects.......Page 48
Renal Effects.......Page 49
Other Effects.......Page 50
2.2.2.4 Neurological Effects......Page 51
2.2.2.5 Developmental Effects......Page 52
2.2.2.7 Genotoxic Effects......Page 53
2.2.3.1 Death......Page 54
2.2.3.2 Systemic Effects......Page 56
Death.......Page 57
Systemic Effects.......Page 58
Neurological Effects.......Page 61
Cancer.......Page 62
2.5 LEVELS IN THE ENVIRONMENT ASSOCIATED WITH LEVELS IN HUMAN TISSUES AND/OR HEALTH EFFECTS......Page 64
2.6.1.1 Inhalation Exposure......Page 65
2.6.2.2 Oral Exposure......Page 67
2.6.3 Metabolism......Page 68
2.6.4.2 Oral Exposure......Page 70
2.7 INTERACTIONS WITH OTHER CHEMICALS......Page 71
2.9 ADEQUACY OF THE DATABASE......Page 72
2.9.1 Existing Information on the Health Effects of 1,2-Dichloropropane......Page 73
Genotoxicity.......Page 75
Neurotoxicity.......Page 76
Bioavailability from Environmental Media.......Page 77
Comparative Toxicokinetics.......Page 78
2.9.3 On-going Studies......Page 79
3.2 PHYSICAL AND CHEMICAL PROPERTIES......Page 81
4.3 USE......Page 85
4.5 ADEQUACY OF THE DATABASE......Page 86
Production, Import, Use, and Disposal.......Page 87
5.1 OVERVIEW......Page 88
5.2.1 Air......Page 89
5.2.2 Water......Page 90
5.3.1 Transport and Partitioning......Page 92
5.3.2.2 Water......Page 94
5.4.1 Air......Page 95
5.4.2 Water......Page 96
5.4.4 Other Media......Page 97
5.5 GENERAL POPULATION AND OCCUPATIONAL EXPOSURE......Page 98
5.7 ADEQUAGY OF THE DATABASE......Page 99
Exposure Registries.......Page 100
5.7.2 On-going Studies......Page 101
6.2 ENVIRONMENTAL SAMPLES......Page 102
Methods for Determining Parent Compounds and Metabolites in Biological Materials.......Page 106
6.3.2 On-going Studies......Page 107
7. REGULATIONS AND ADVISORY STANDARDS......Page 108
8. REFERENCES......Page 110
EPA Health Advisory --......Page 124
Minimal Risk Level......Page 125
Reproductive Toxicity......Page 126
Uncertainty Factor (UF)......Page 127
APPENDIX: PEER REVIEW......Page 128