The field of toxicology has developed a well-characterized set of techniques to assess the behavioral and histopathological consequences of exposure to environmental insults using a number of animal models. These techniques are suitable for determining crude endpoints of exposure such as death, but are not optimal for assessing the more subtle effects of very low level or multi-agent chemical exposures, nor do they offer mechanistic explanations at the molecular level. This book is designed to have a mix of chapters devoted to classical toxicology followed by those focused more on the emerging techniques of toxicogenomics and proteomics. In this way, the relevance of new technologies such as gene arrays to classical toxicologic problems is made evident. Finally, because the worst of the world's toxicology problems reside in developing nations while the latest technical developments are occurring in the industrial nations, we sought to provide a balance of both scientific and geographical perspectives from researchers engaged in toxicology and public health research.
IOS Press is an international science, technical and medical publisher of high-quality books for academics, scientists, and professionals in all fields.
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-Biomedicine -Oncology -Artificial intelligence -Databases and information systems -Maritime engineering -Nanotechnology -Geoengineering -All aspects of physics -E-governance -E-commerce -The knowledge economy -Urban studies -Arms control -Understanding and responding to terrorism -Medical informatics -Computer Sciences
Author(s): Czech Republic) NATO Advanced Research Workshop on Toxicogenomics and Proteomics (2002 : Prague, James J. Valdes, Jennifer W. Sekowski
Series: NATO Science series. Life and behavioural sciences Series I 356
Edition: 1
Publisher: IOS Press
Year: 2004
Language: English
Pages: 216
City: Amsterdam; Washington, DC
Cover......Page 1
Title page......Page 2
Foreword......Page 6
Contents......Page 8
Systems Biology......Page 10
The Role of Bioinformatics in Toxicogenomics and Proteomics......Page 18
Interpretation of Global Gene Expression Data through Gene Ontologies......Page 34
Expanding the Information Window to Increase Proteomic Sensitivity and Selectivity......Page 42
Understanding the Significance of Genetic Variability in the Human PON1 Gene......Page 52
Functional Genomics Methods in Hepatotoxicity......Page 64
The Toxicogenomics of Low-level Exposure to Organophosphate Nerve Agents......Page 84
Molecular Biomarkers......Page 96
Expression Profiling of Sulfur Mustard Exposure in Murine Skin: Chemokines, Cytokines and Growth Factors......Page 118
Further Progress in DNA Repair Puzzle in the Postgenomics Era......Page 126
Non-Ribosomal Peptide Synthetases for the Production of Bioactive Peptides with Syringomycin Synthetase as an Example......Page 134
Bacterial Genomics and Measures for Controlling the Threat from Biological Weapons......Page 144
An Evaluation of Toxins and Bioregulators as Terrorism and Warfare Agents......Page 156
Prospects on Immunoassays for the Detection of Pesticides in the Environment......Page 168
Prospects for Holographic Optical Tweezers......Page 190
G......Page 212
P......Page 213
X......Page 214
Author Index......Page 216
