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Thrombin: Physiology and Disease

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It has become increasingly evident in recent years that, apart from the key role that thrombin plays in the blood coagulation cascade, thrombin also elicits cellular actions via the activation of proteinase-activated receptors, which are present in many cell types. These effects of thrombin are seen in a variety of physiological as well as pathological phenomena, including vascular development and physiology, tumor progression and metastasis, neuronal functions, inflammation, angiogenesis. Thrombin: Physiology and Disease, edited by Michael E. Maragoudakis and Nikos E. Tsopanoglou, emphasizes the new developments in this important field of research and provides the basis for translating these findings into therapeutic targets."

Author(s): Enrico Di Cera*, Andras Gruber (auth.), Michael E. Maragoudakis, Nikos E. Tsopanoglou (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2009

Language: English
Pages: 266
Tags: Cancer Research; Pharmacology/Toxicology; Biochemistry, general; Epidemiology

Front Matter....Pages i-xii
Thrombin: Structure, Functions, and Regulation....Pages 1-18
Thrombin: To PAR or Not to PAR, and the Regulation of Inflammation....Pages 19-46
Regulation of Thrombin Receptor Signaling....Pages 47-61
Thrombin-Activated Protein C: Integrated to Regulate Vascular Physiology....Pages 63-80
The Role of Thrombin in Vascular Development....Pages 81-92
The Role of Thrombin in Angiogenesis....Pages 93-113
Thrombin and Thrombin Peptides in Wound Healing and Tissue Repair....Pages 115-132
The Role of Thrombin and Thrombin Receptors in the Brain....Pages 133-159
The Role of Thrombin in Tumor Biology....Pages 161-172
The Role of Thrombin and its Receptors in Epithelial Malignancies: Lessons from a Transgenic Mouse Model and Transcriptional Regulation....Pages 173-188
Anti-thrombotic Therapy in Cancer Patients....Pages 189-203
Thrombin Receptor Modulators: Medicinal Chemistry, Biological Evaluation, and Clinical Application....Pages 205-236
Novel Anticoagulant Therapy: Principle and Practice....Pages 237-257
Back Matter....Pages 259-266