The volume includes contributions by some of the leading scientists in the field of thiol oxidation/reduction (redox) biochemistry, focused on the biological/pathophysiological implications of newly discovered functions of cellular thiols, such as glutathione in the first place. Recent research has shown that thiols - besides their well established role in cell defense against prooxidant damage - can mediate physiological functions of free radicals and other prooxidants, e.g. in modulation of protein synthesis and folding, signal transduction, cell proliferation. The volume is timely addressing many of these novel and intriguing insights, adding elements for a better understanding of the role of redox processes in important human pathologies, such as atherosclerosis, ischemia-reperfusion, cancer and Alzheimer's disease.
Author(s): Italy) NATO Advanced Research Workshop on Thiol Metabolism and Redox Regulation of Cellular Functions (2002 : Pisa, Alfonso Pompella, Gabor Banhegyi, Maria Wellman-Rousseau
Series: NATO science series. Life and behavioural sciences Series I 347
Publisher: IOS Press
Year: 2002
Language: English
Pages: 365
City: Amsterdam; Washington, DC
Cover......Page 1
Title page......Page 2
Foreword......Page 6
Preface......Page 8
Contributors......Page 9
Contents......Page 12
Oxidative Signaling and Glutathione Synthesis......Page 16
Cell Survival and Changes in Gene Expression in Cells Unable to Synthesize Glutathione......Page 29
Role of Glutathione in the Regulation of Liver Metabolism......Page 37
Glutathione Transport in the Endo/Sarcoplasmic Reticulum......Page 44
Role of Ascorbate in Oxidative Protein Folding......Page 53
Cytophotometric Investigations on Oscillating Thiol-Disulfide Equilibria and Oxidized Protein Sulfur......Page 63
Protection by Pantothenic Acid against Apoptosis and Cell Damage by Oxygen Free Radicals - The Role of Glutathione......Page 76
Thiols as Major Determinants of the Total Antioxidant Capacity......Page 90
Enzymes of the Thiol-dependent Hydroperoxide Metabolism in Pathogens as Potential Drug Targets......Page 100
Is there a Role of Glutathione Peroxidases in Signaling and Differentiation?......Page 111
Multidrug Resistance-associated Proteins: Export Pumps for Conjugates with Glutathione, Glucuronate or Sulfate......Page 122
Detoxification of Electrophilic Compounds by Glutathione S-Transferase Catalysis: Determinants of Individual Response to Chemical Carcinogens and.........Page 134
Transcriptional Regulation of Glutathione S-Transferase P1-1 in Human Leukemia......Page 153
Mechanism of γ-Glutamyltranspeptidase Folding and Activation in the Endoplasmic Reticulum......Page 161
The Role of γ-Glutamyl Transpeptidase in the Biosynthesis of Glutathione......Page 175
Role of γ-Glutamyltransferase in the Homeostasis of Glutathione during Oxidative and Nitrosative Stress......Page 187
The Importance of gamma-Glutamyl Transferase in Lung Glutathione Homeostasis and Antioxidant Defense......Page 197
The Role of gamma-Glutamyltranspeptidase in the Metabolism and Cytotoxicity of 4-Hydroxynonenal-Glutathione Conjugate: Evidence and Hypothesis......Page 212
γ-Glutamyltransferase-Dependent Prooxidant Reactions: a Factor in Multiple Processes......Page 224
Serum gamma-Glutamyl Transpeptidase: a Prognostic Marker in Cardiovascular Diseases......Page 238
Lipoic Acid: a Multifunctional Antioxidant......Page 245
Is Glutathione an Important Neuroprotective Effector Molecule against Amyloid Beta Toxicity?......Page 253
Antioxidants in Cancer Therapy: is there a Rationale to Recommend Antioxidants during Cancer Therapy?......Page 267
Disulfide Exchange in CD4......Page 280
Redox Regulation in Protein Folding and Chaperone Function......Page 288
Reduction of the Endoplasmic Reticulum Accompanies the Oxidative Damage of Diabetes Mellitus......Page 296
Analytical Developments in the Assay of Intra- and Extracellular GSH Homeostasis......Page 305
Signalling Potential and Protein Modifying Ability of Physiological Thiols......Page 314
Redox Signaling and the Map Kinase Pathways......Page 321
Redox Regulation of Mitochondrial Permeability Transition: Contrasting Effects of Lipoic Acid and its Positively Charged Analog LA-Plus......Page 332
Redox State of Glutathione and Thioredoxin in Differentiation and Apoptosis......Page 343
Redox Regulation of DNA Repair......Page 353
S......Page 364
Y......Page 365
