This book highlights the recent advances of thermodynamics and biophysics in drug delivery nanosystems and in biomedical nanodevices. The up-to-date book provides an in-depth knowledge of bio-inspired nanotechnological systems for pharmaceutical applications.
Biophysics and thermodynamics, supported by mathematics, are the locomotive by which the drug transportation and the targeting processes will be achieved under the light of the modern pharmacotherapy. They are considered as scientific tools that promote the understanding of physicochemical and thermotropic functionality and behavior of artificial cell membranes and structures like nanoparticulate systems. Therefore, this book focusses on new aspects of biophysics and thermodynamics as important elements for evaluating biomedical nanosystems, and it correlates their physicochemical, biophysical and thermodynamical behaviour with those of a living organism.
In 2018, Prof. Demetzos was honored with an award by the Order of Sciences of the Academy of Athens for his scientific contribution in Pharmaceutical Nanotechnology.
Author(s): Costas Demetzos, Natassa Pippa
Series: Series in BioEngineering
Publisher: Springer
Year: 2019
Language: English
Pages: 475
City: Cham
Front Matter ....Pages i-xii
Introducing Thermodynamics and Biophysics in Health Sciences (Costas Demetzos, Natassa Pippa)....Pages 1-11
Methodological Approaches for the Characterization of the Self-assembling Behaviour in the Pharmaceutical Field (Diego Romano Perinelli, Giulia Bonacucina)....Pages 13-37
Phase Transitions in Biological Membranes (Thomas Heimburg)....Pages 39-61
Isothermal Titration Calorimetry: A Powerful Tool for the Characterization of Molecular Interactions (Angelos Thanassoulas, George Nounesis)....Pages 63-103
Dynamics of Iron Homeostasis in Health and Disease: Molecular Mechanisms and Methods for Iron Determination (Christina Ploumi, Emmanouil Kyriakakis, Nektarios Tavernarakis)....Pages 105-145
Achieving Selective Targeting Using Engineered Nanomaterials (Roberta Lanfranco, Bortolo M. Mognetti, Gilles Bruylants)....Pages 147-182
PAMAM and PPI Dendrimers in Biophysical and Thermodynamic Studies on the Delivery of Therapeutic Nucleotides, Nucleosides and Nucleobase Derivatives for Anticancer Applications (Michał Gorzkiewicz, Adam Buczkowski, Bartłomiej Pałecz, Barbara Klajnert-Maculewicz)....Pages 183-243
Thermal Analysis of Glass-Ceramics and Composites in Biomedical and Dental Sciences (George S. Theodorou, Dimitra Patsiaoura, Eleana Kontonasaki, Konstantinos Chrissafis)....Pages 245-295
Differential Scanning Calorimetry (DSC): An Invaluable Tool for the Thermal Evaluation of Advanced Chimeric Liposomal Drug Delivery Nanosystems (Maria Chountoulesi, Nikolaos Naziris, Natassa Pippa, Stergios Pispas, Costas Demetzos)....Pages 297-337
Drug-Membrane Interactions in the Renin Angiotensin System (Dimitrios Ntountaniotis, Tahsin F. Kellici, Paraskevi Gkeka, Zoe Cournia, Ioannis Galdadas, Gregor Mali et al.)....Pages 339-364
Biophysical Characterization of Polysialic Acid—Membrane Nanosystems (Karolina Sapoń, Teresa Janas, Tadeusz Janas)....Pages 365-396
Self-assembling of Thermo-Responsive Block Copolymers: Structural, Thermal and Dielectric Investigations (A. Kyritsis, A. Laschewsky, C. M. Papadakis)....Pages 397-444
Sol-Gel Synthesis and Characterization of Hybrid Materials for Biomedical Applications (Michelina Catauro, Stefano Vecchio Ciprioti)....Pages 445-475
