Prostate cancer accounts for nearly a quarter of all male cancers, and the incidence is rising as detection rates continue to improve, and life expectancy increases. Timely intervention affords a wider range of management options and in this new volume the editors review the choices available. In the first section lifestyle interventions, such as nutrition and screening, and evaluation of risk factors are discussed; then follows an update on management strategies for localised and locally advanced cancer in various risk groups, drawing on the results of the latest clinical trials. The third section of the book looks at advanced cancer including the management of metastases, and encompasses hormonal and chemotherapy, and palliative care. The volume concludes with a review of common complications of prostate cancer such as urinary obstruction and erectile dysfunction, and appropriate strategies for pain control. Among the key topics discussed: the evidence for and against PSA screening; the value of current prognostic models in predicting clinical outcomes; the role of biomarkers in evaluating therapeutic success; How to determine the endpoint of clinical trials; and, new horizons in chemotherapy for prostate cancer. This new work addresses questions which challenge every clinician involved with the care of cancer patients today, and provides authoritative insights into the thinking that will define best practice in future.
Author(s): Mark R. Fenely, Heather A. Payne
Edition: 1
Year: 2007
Language: English
Pages: 285
Contents......Page 4
Editors and Conributors......Page 6
Section I: Prevention and diagnosis
......Page 9
1. Nutrition, lifestyle interventions and prevention......Page 10
2. The current state of biomarkers for prostate cancer
......Page 31
3. Histopathological markers and precursor lesions......Page 49
4. Prostate cancer screening......Page 73
Section II: Regional prostate cancer – localized and locally advanced cancer
......Page 83
5. Assessment of treatment strategies in prostate cancer using risk stratification and prediction of clinical outcomes......Page 84
6. Conservative treatment strategies for localized favourable-risk prostate cancer......Page 94
7. Treatment of low-risk prostate cancer......Page 104
8. Treatment strategies for high-risk prostate cancer......Page 119
9. Treatment strategies for biochemical recurrence of prostate cancer......Page 138
Section III: Advanced prostate cancer – distant metastases......Page 151
10. Advanced prostate cancer – distant metastases: endpoints for clinical trials
......Page 152
11. Hormonal therapy......Page 163
12. Chemotherapeutic strategies for treatment of advanced disease......Page 176
13. Molecular strategies and clinical trial design in the treatment of advanced prostate cancer......Page 194
14. Therapeutic strategies of palliative care and quality of life for advanced prostate cancer......Page 204
Section IV: Management of complications......Page 216
15. Treatment strategies for spinal cord compression and fractures
......Page 217
16. Treatment strategies for urinary obstruction......Page 234
17. Treatment strategies for erectile dysfunction......Page 243
18. Therapeutic strategies for pain......Page 257
Abbreviations......Page 270
Index......Page 272
