The Vascular Endothelium: A Holistic Approach for Oncology provides novel and integrated knowledge on the endothelial cells as a crucial component involved in the growth of different organs in both physiological and pathological conditions. By covering diverse aspects of anatomy, embryology, molecular biology and pathology, it details the important role of the endothelium for the pathogenesis of cancer and how this knowledge can improve the outcome of cancer research.
The content is split in six parts: appearance and evolution of the endothelial cell, which discusses for instance comparative anatomy of the endothelium in relation to the vascular system; endothelial cell in embryology and organogenesis, covering the interaction between endothelial and hematopoietic cells; the lymphatic system, which brings information on lymphatic endothelial cell markers and molecular regulation of lymphangiogenesis; the anatomy of the endothelium in adults, showing the differences in the mature endothelial cells through the body; the physiology of the endothelial cells, with organ specific physiological activity of the endothelium; and the endothelial cells in cancer, discussing the use of endothelium as target for treatment and current therapeutic approaches.
This book is a valuable resource for cancer researchers, oncologists and other members of biomedical field who are interested to learn more about the complexity of vascular endothelium and its impact on cancer and other related diseases.
Author(s): Domenico Ribatti, Francesco Pezzella
Publisher: Academic Press
Year: 2022
Language: English
Pages: 135
City: London
The Vascular Endothelium
Copyright
1. Appearance and evolution of the endothelial cell
1.1 Appearance of a circulatory system
1.2 Coeloma, the basic circulatory system
1.3 The hemel, vascular channel without endothelium
1.4 The oldest endothelium
1.5 Why there are advantages in an endothelium-lined vessel?
1.6 How endothelium evolved?
1.7 Conclusions
References
2. Endothelial cell in embryology and organogenesis
2.1 Vasculogenesis and angiogenesis
2.2 Prenatal vasculogenesis
2.3 Postnatal vasculogenesis
2.4 Angiogenesis
2.4.1 Endothelial tip, stalk, and phalanx cells
2.4.2 Lumen formation and perfusion
2.4.3 Network formation
2.4.4 Recruitment of mural cells
2.4.5 Vascular branching, pruning, and remodeling
2.4.6 Formation of arteries and veins
2.4.7 Hemodynamic forces
2.4.8 Variations in EC gene expression and interplay between genetic and epigenetic factors
2.4.9 Organ-specific capillary structures
2.4.10 Angiogenesis and organogenesis
2.5 The relationship between endothelial and hematopoietic cells
2.5.1 Endothelial precursor cells
2.5.2 Recruitment of EPCs to sites of active neovascularization and the role of EPCs in tumor vascularization
2.5.3 The role of Epo in tumor angiogenesis
2.5.4 The role of G-CSF and GM-CSF in tumor angiogenesis
References
3. The lymphatic system
3.1 Lymphangiogenesis
3.2 Structural features of the lymphatic system and lymphatic endothelial cell markers
3.3 Molecular regulation of lymphangiogenesis
References
4. The physiology of the endothelial cells
4.1 Introduction
4.2 Different types of vessels
4.2.1 Arteries, veins, and capillaries
4.2.2 Different types of capillaries
4.2.2.1 Continuous capillary
4.2.2.2 Fenestrated capillary
4.2.2.3 Discontinuous capillary
4.3 The main physiological functions of the endothelial cells
4.4 The interaction between endothelial cells
4.4.1 Adherens junction family
4.4.2 Tight junction family
4.4.3 The gap junctions and the connexin family
4.4.4 PECAM-1, CD99, and ESAM
4.5 Adhesion with the basement membrane
4.6 Angiocrine activity of endothelial cells
4.7 Endothelium as a barrier: exchange of oxygen, nutrients plus other metabolites, and catabolites
4.8 Respiration: molecules diffusion through the endothelium
4.9 Glucose transport: diffusion carrier and bulk flow
4.10 Control of the vascular tone
4.11 The metabolism of the endothelial cells
4.12 The nonproliferating endothelium: maintaining the homeostasis
4.12.1 Glucose and oxygen
4.12.2 Insulin
4.12.3 Fatty acids
4.13 The proliferating endothelium
4.14 Immune response: recruitment and transit regulation of immune cells
4.15 Triggers for endothelial leukocytes active interaction
4.16 The interaction between endothelium and immune cells in inflammation
4.17 The high endothelium venules in lymphatic organs
4.18 Hemostasis and the endothelium
References
5. The ultrastructure of the endothelial cells
References
6. The endothelial cells in cancer: an outline
6.1 Endothelial cells in intratumor vessels
6.2 Specific studies on endothelium from co-opted normal preexisting vessels
6.3 High throughput studies
6.4 Metabolism of intratumor endothelium
6.5 Immunity and intratumor endothelium
6.6 Vasculogenic mimicry
6.7 Endothelial cells with aneuploidy
6.8 Endothelial cells harboring the tumor chromosomal abnormalities
6.9 Endothelial cells with chromosomal instability
6.10 Circulating endothelial cells in cancer patients
6.11 Endothelium as target for treatment
References
Index
A
B
C
D
E
F
G
H
I
J
L
M
N
O
P
R
S
T
U
V
W
Z
