This SpringerBrief explores unconventional functions of eight different transcription factors and concludes with a discussion of their biological significance and impact, including effects on processes within the cell nucleaus during development and in adult organisms. Chapter One details unconventional functions of the transcription factors GAGA, HP1, Rb, STAT, ATF-2 and NF-kB. Surprisingly, all of these transcription factors can be found in association with heterochromatin as well as euchromatin, and in some cases unconventional functions have been demonstrated for these heterochromatin-associated factors. Chapter Two focuses on the unconventional functions of STAT and HP1 and discusses their roles in the promotion of longevity, and in protection from cancer and DNA damage. Chapter Three explores the biological significance of the findings presented in the first two chapters and considers how global changes in the epigenome brought about by factors such as STAT and HP1 might affect processes within the cell nucleus during development and in adult organisms. This succinct yet thorough SpringerBrief is essential for researchers studying epigenetics, and to instructors of the subject. It should also appeal to people interested in the control of gene transcription and other processes in the cell nucleus, and to those interested in development.
Author(s): Willis X. Li, Louise Silver-Morse
Series: SpringerBriefs in Biochemistry and Molecular Biology
Publisher: Springer
Year: 2023
Language: English
Pages: 61
City: Cham
Contents
Chapter 1: HP1 and Noncanonical Functions of STAT
STAT
HP1
Summary
References
Chapter 2: Biological Functions of STAT, HP1, and Heterochromatin
Heterochromatin Loss During Aging
Heterochromatin Redistribution in Cellular Senescence
Cellular Senescence Versus Cancer Development
STAT and HP1 Protect Against DNA Damage and Promote Longevity
References
Chapter 3: Other Transcription Factors with Noncanonical Functions in Heterochromatin Regulation
GAGA Factor
Rb
ATF2
NF-κB
PAX
C/EBPα
References
Chapter 4: HP1 in Liquid–Liquid Phase Separation and its Regulation by 53BP1
Liquid–Liquid Phase Separation and HP1
53BP1
53BP1 and Proteins in DNA Damage Response
Cell Cycle Phase-Dependent DNA Damage Repair
Other Pathways in DNA Damage Response
53BP1 in Heterochromatin Regulation
References
Index
