The Rho GTPases in Cancer is the first volume to collect and summarize the current understanding of the Rho GTPases and their involvement in the progression of human cancer. The critical role of the Rho GTPases, their regulatory proteins, and their effectors in cancer progression has become increasingly evident over the past decade. As translational research increases on these proteins, their importance as keystone molecules in vital cellular process is highlighted. Thus, these molecules represent a major class of potential therapeutic targets that could be exploited clinically. This aspect of Rho GTPase biology is developing, therefore the contents of The Rho GTPases in Cancer should prove of interest to clinicians and members of the cancer research community wishing to develop new treatments for cancer.
Author(s): Ellen V. Stevens, Channing J. Der (auth.), Kenneth Golen (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2010
Language: English
Pages: 206
Tags: Cancer Research; Cell Biology; Pharmacology/Toxicology
Front Matter....Pages i-xxii
Front Matter....Pages 1-1
Overview of Rho GTPase History....Pages 3-27
Rho Proteins in Cancer....Pages 29-42
Front Matter....Pages 44-44
RhoGDIs in Cancer....Pages 45-58
Signaling through Galpha12/13 and RGS-RhoGEFs....Pages 59-76
Vav Proteins in Cancer....Pages 77-92
Rho GTPase-Activating Proteins in Cancer....Pages 93-107
Front Matter....Pages 110-110
RhoBTB Proteins in Cancer....Pages 111-122
RhoC GTPase in Cancer Progression and Metastasis....Pages 123-134
RhoB GTPase and FTIs in Cancer....Pages 135-153
Regulation of Rho GTPase Activity Through Phosphorylation Events: A Brief Overview....Pages 155-162
The Rho-Regulated ROCK Kinases in Cancer....Pages 163-192
Back Matter....Pages 193-206