Author(s): Francis X. McConville
Edition: First
Publisher: FXM Engineering and Design
Year: 2002
Language: English
Pages: 309
City: Worcester MA
1 The Pilot Plant
Role of the Plant · Factors in Scale-Up · Some Do's and Don'ts · Tips for Developing Scalable
Reactions · Calorimetry/Safety Screening · Haz-Ops · Flow Diagrams · Batch Records · GMP
2 Equipment and Operations
Equipment Train · Reactors · Agitation · Raw Material Charging · Reaction Control · Sampling
• Workup · Distillation · Crystallization · Isolation/Filtration · Drying · Equipment Cleaning
3 Liquid Handling
Pumps · Pump Sizing, Selection and Troubleshooting · Pipes, Fittings and Valves · Flanges and
Gaskets · Hose · Friction and Viscosity Effects · O-rings · Stoppers · Liquid Storage Vessels
4 Heat Transfer
Heat Transfer in Stirred Vessels · Heat Exchangers · Temperature Control Units · Heat Transfer
Fluid Selection and Properties · Glycols and Brines · Steam · Process Chillers
5 Electricity and Instrumentation
Electrical Safety · Electric Power Basics · Receptacle Types · Electrical Enclosure Data ·
Intrinsic Safety · Motors · Temperature, Pressure and pH Measurement · Process Control Basics
6 Solvents
Safe Handling · Properties and Selection · Solubility Map · Temperature/Vapor Pressure Rela
tionships · Distillation · Binary Azeotropes · Ternary Water-Containing Azeotropes · Water Data
7 Compressed Gases
Safe Handling · Physical Properties · Cryogenic Liquids · Cylinder Specifications · Connection
Data · Pressure Regulators · Gas Metering · Air Data · Air Compressors · Vacuum Systems
8 Chemical Data
Properties of Acids and Bases · Dilutions · pKas · pH Buffers · Color Indicators · Aqueous
Solubility Data · Aqueous Solution Density · Organic Functional Groups · Reaction Types
9 Chemical Hygiene and Safety
Safe Handling of Chemicals · MSDSs · Hazards Classifications · Labeling · Fire Safety ·
Personal Protective Equipment · Glove Selection · Respirators · Incompatible Chemicals
10 Materials Selection
Properties of Elastomers, Plastics, Metals and Glass · Metallic Corrosion Data · Glass Corrosion
• Material Compatibility Table
11 Miscellaneous
Unit Conversion Tables · Physical Constants · Mathematical Relationships · Geometric Formu
las · Temperature/Pressure Conversion Charts · Cold Mixtures · Sieve Sizes · Agency Acronyms
Bibliography
Additional Recommended Reading
Index
