The nucleus of a cell contains its DNA and is the site where DNA replication, transcription, and RNA processing take place. Nuclei have many domains but lack the membrane-bound organelles characteristic of the cytoplasm. Instead, nuclear bodies appear to dynamically self-organize, assembling and disassembling according to the functional demands of the cell. Written and edited by experts in the field, this volume includes contributions discussing the relationship between nuclear structure and function, the various nuclear bodies that have been identified, and the organization of the nuclear lamina and nuclear pore complex. Other contributions examine the higher-order organization of chromatin within the nucleus and the dynamics of DNA replication, transcription, DNA repair, and RNA transport. Including a historical introduction to the field and discussion of the numerous pathological conditions involving disruption of nuclear structure and function, this volume is essential reading for all molecular and cell biologists, as well as pathologists interested in the role of nuclear architecture in disease
Author(s): David L. Spector, Tom Misteli (editors)
Edition: 1
Publisher: Cold Spring Harbor Laboratory Press
Year: 2010
Language: English
Commentary: Missing appendix, incorrect page numbers.
Pages: 463
Tags: Биологические дисциплины;Цитология;
Cover......Page 1
Contents......Page 2
The Nucleus Introduced......Page 6
The Nuclear Envelope......Page 22
Nuclear Lamins......Page 38
Lamin-binding Proteins......Page 60
The Nuclear Pore Complex and Nuclear Transport......Page 77
Chromosome Territories......Page 96
Gene Positioning......Page 118
ChromatinHigher-orderStructureandDynamic......Page 135
Nuclear Organization and Dosage Compensation......Page 160
The Budding Yeast Nucleus......Page 175
Nuclear Functions of Actin......Page 195
The Nucleolus......Page 208
Nuclear Speckles......Page 223
The Cajal Body and Histone Locus Body......Page 235
PML Nuclear Bodies......Page 247
The Perinucleolar Compartment......Page 264
Paraspeckles......Page 274
Nuclear Stress Bodies......Page 288
Orphan Nuclear Bodies......Page 300
Biogenesis of Nuclear Bodies......Page 311
Organization of Transcription......Page 326
Organization of DNA Replication......Page 341
DNA Damage Response......Page 354
RNA Processing and Export......Page 373
Diseases of the Nuclear Envelope......Page 393
Higher-order Genome Organization in Human Disease......Page 410
Nuclear Ataxias......Page 427
Developments in RNA Splicing and Diseas......Page 438
Index......Page 452
Backcover......Page 463
