The Neuroimmunological Basis of Behavior and Mental Disorders

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Over the past three decades, the neuroscience community has seen the rapid growth of neuroimmunology, a new area of research investigating how immune activation and immune-derived products interact with the brain and modulate behavior. A convergence of multidisciplinary investigators helped launch this field by developing several groundbreaking lines of research, including the characterization of neuroimmune feedback loops, development of an understanding of sickness behavior, the role of cytokines in modulating normal and abnormal neurochemical and behavioral functions, clinical studies linking mental disorders with alterations in immune function, and identification of the molecular substrates governing the neuroimmunological basis of behavior and mental disorders. The Neuroimmunological Basis of Behavior and Mental Disorders includes contributions from outstanding scientists, and clinicians who have made major contributions to one or more of the subsets of this rapidly developing field. This book will be of particular interest and use to scientists, clinicians, students, educators, and workers in the field of neuroscience and related disciplines involving the study of normal and abnormal behavior.

About the Editors:

Allan Siegel, Ph.D., was awarded his doctorate from the State University of New York at Buffalo in 1966 and was trained in the fields of Neurophysiology, Neuroanatomy and Behavioral Neuroscience at Yale University School of Medicine. He is Professor of Neurology and Neuroscience and Psychiatry at New Jersey Medical School's University of Medicine and Dentistry in Newark, New Jersey. His research focuses on the anatomical substrates and neurochemical mechanisms, including the functions of cytokines, governing aggression, and rage behavior.

Steven S. Zalcman, Ph.D., was awarded his doctorate from Carleton University, Ottawa, Canada in 1990, and was a postdoctoral fellow at the Manitoba Institute of Cell Biology, University of Manitoba Medical School. He received training in Behavioral Neuroscience, Neurochemistry, Anatomy, and Immunology. He held a faculty position in the Department of Psychology, Concordia University, Montreal, Canada, and is presently Associate Professor of Psychiatry at New Jersey Medical School's University of Medicine and Dentistry in Newark, New Jersey. His research focuses on neurochemical, neuropharmacological, and behavioral consequences of immune activation and cytokine treatment.

Author(s): William A. Banks, Jessica L. Lynch, Tulin O. Price (auth.), Allan Siegel, Steven S. Zalcman (eds.)
Edition: 1
Publisher: Springer US
Year: 2009

Language: English
Pages: 438
Tags: Neurosciences; Psychopharmacology; Immunology; Psychiatry; Neurobiology

Front Matter....Pages I-XV
Front Matter....Pages 1-1
Cytokines and the Blood–Brain Barrier....Pages 3-17
Neurochemical and Endocrine Responses to Immune Activation: the Role of Cytokines....Pages 19-33
Neural Pathways Mediating Behavioral Changes Associated with Immunological Challenge....Pages 35-58
Molecular Basis of Cytokine Function....Pages 59-70
Interferon-α, Molecular Signaling Pathways and Behavior....Pages 71-85
Exercise and Stress Resistance: Neural-Immune Mechanisms....Pages 87-107
Front Matter....Pages 109-109
Alteration of Neurodevelopment and behavior by Maternal Immune Activation....Pages 111-130
Interleukin-2 and Septohippocampal Neurons: Neurodevelopment and Autoimmunity....Pages 131-143
Cytokine-Induced Sickness Behavior and Depression....Pages 145-181
Effect of Systemic Challenge with Bacterial Toxins on Behaviors Relevant to Mood, Anxiety and Cognition....Pages 183-208
Cytokines, Immunity and Sleep....Pages 209-233
Cytokines and Aggressive Behavior....Pages 235-259
Neurochemical and Behavioral Changes Induced by Interleukin-2 and Soluble Interleukin-2 Receptors....Pages 261-284
Front Matter....Pages 285-285
Immunity and Depression: A Clinical Perspective....Pages 287-305
Cytokines, Immunity and Schizophrenia with Emphasis on Underlying Neurochemical Mechanisms....Pages 307-325
Immunobiological and Neural Substrates of Cancer-Related Neurocognitive Deficits....Pages 327-340
Autoimmunity and Brain Dysfunction....Pages 341-381
Viruses and Psychiatric Disorders....Pages 383-410
Microglial Cells and Inflammatory Cytokines in the Aged Brain....Pages 411-423
Back Matter....Pages 425-438