The book describes the mechanisms involved in the maintenance of neuroendocrine-immune interactions in ageing. The lack of this maintenance leads to the appearance of age-related diseases (cancer, infections, dementia) and subsequent disability. The capacity of some hormones or nutritional factors in restoring and remodelling the neuroendocrine-immune response during ageing is reported presenting possible new anti-ageing strategies in order to reach healthy ageing and longevity.
Author(s): Rainer H. Straub and Eugenio Mocchegiani (Eds.)
Series: NeuroImmune Biology 4
Publisher: Elsevier Science
Year: 2005
Language: English
Pages: 3-441
Content:
List of contributors
Pages v-x
Evolutionary aspects for the neuroendocrine immune network in ageing Original Research Article
Pages 3-6
Rainer H. Straub
Immunosenescence Original Research Article
Pages 9-21
Rafael Solana, Graham Pawelec
Zinc-binding proteins (metallothionein and α-2 macroglobulin) as potential biological markers of immunosenescence Original Research Article
Pages 23-40
Eugenio Mocchegiani, Robertina Giacconi, Elisa Muti, Mario Muzzioli, Catia Cipriano
Neutrophil ageing and immunosenescence Original Research Article
Pages 41-55
Stephen K Butcher, Keqing Wang, David Lascelles, Janet M Lord
Apoptosis and ageing Original Research Article
Pages 57-72
Anis Larbi, Tamas Fulop
MHC-unrestricted cytotoxicity in ageing Original Research Article
Pages 73-89
Mauro Provinciali, Alessia Donnini, Francesca Re
Major histocompatibility complex polymorphisms and ageing Original Research Article
Pages 91-101
Giuseppina Candore, Calogero Caruso, Giuseppina Colonna-Romano, Domenico Lio
Neuroplasticity in the human hypothalamus during ageing Original Research Article
Pages 105-121
Michel A. Hofman, Dick F. Swaab
The role of growth hormone signaling in the control of ageing Original Research Article
Pages 123-137
A. Bartke, M. Heiman, D. Turyn, F. Dominici, J.J. Kopchick
Ageing and the adrenal cortex Original Research Article
Pages 139-152
V. Lamounier-Zepter, S.R. Bornstein
Hormonal changes in ageing men Original Research Article
Pages 153-163
Eugen Plas, Stephan Madersbacher, Peter Berger
Ageing and the endocrine circadian system Original Research Article
Pages 165-193
Yvan touitou, Erhard Haus
Melatonin rhythms, melatonin supplementation and sleep in old age Original Research Article
Pages 195-211
Rixt F. Riemersma, Caroline A.M. Mattheij, Dick F. Swaab, Eus J.W. Van Someren
Age-related changes of the human autonomic nervous system Original Research Article
Pages 215-231
Marcus W. Agelink, Dirk Sanner, Dan Ziegler
Age-related alterations in autonomic nervous innervation Original Research Article
Pages 233-255
Denise L. Bellinger, Kelley S. Madden, Dianne Lorton
Ageing and the neuroendocrine system of the gut Original Research Article
Pages 257-271
Magdy El-Salhy
Modulating effects of nutrition on brain ageing Original Research Article
Pages 273-289
Carlo Bertoni-Freddari, Patrizia Fattoretti, Tiziana Casoli, Giuseppina Di Stefano, Moreno Solazzi, Belinda Giorgetti, Marta Balietti
Ageing-related role of nitric oxide in the brain Original Research Article
Pages 291-300
Sofia Mariotto, Massimo Miscusi, Tiziana Persichini, Marco Colasanti, Hisanori Suzuki
Introduction: Links between one global system and another global system during the ageing process Original Research Article
Pages 303-305
Rainer H. Straub
Plasticity of neuroendocrine-thymus interactions during ontogeny and ageing: Role of zinc Original Research Article
Pages 307-329
Eugenio Mocchegiani, Robertina Giacconi, Elisa Muti, Mario Muzzioli, Catia Cipriano
Adverse glucocorticoid actions and their relevance to brain ageing Original Research Article
Pages 331-346
Klaus Dinkel, Robert M. Sapolsky
Neuroendocrine immune aspects of osteoporosis during the ageing process Original Research Article
Pages 347-359
Meinrad Peterlik
Neuroendocrine immune mechanisms of accelerated ageing in patients with chronic inflammatory diseases Original Research Article
Pages 363-374
Rainer H. Straub, Jürgen Schölmerich, Maurizio Cutolo
Thyroid autoimmunity and ageing Original Research Article
Pages 375-382
Stefano Mariotti, Giovanni Pinna, Aldo Pinchera
The clinical importance of proinflammatory cytokines in elderly populations Original Research Article
Pages 383-395
Helle Bruunsgaard, Karen Krabbe
Possible new anti-ageing strategies related to neuroendocrine-immune interactions Original Research Article
Pages 399-407
Eugenio Mocchegiani, Rainer H. Straub
Concluding remarks and future directions Original Research Article
Pages 409-427
Istvan Berczi, Andor Szentivanyi
Index
Pages 429-441
