The inflammasome was first described in 2002 as a molecular complex activating proinflammatory caspases and therefore regulating the maturation and biological activities of cytokines such as IL-1 and IL-18. This finding was substantiated by the identification of several mutations in the cias1 gene, encoding the human NLRP3 protein, responsible for several autoinflammatory disorders such as the Muckle Wells syndrome. Since, the interest for this complex has constantly increased and several inflammasome complexes with different specificities have been described. These inflammasomes sense a wide variety of pathogens and danger signals and are key players in the inflammatory response. With the contributions of leading international experts in the field, this book provides an extensive overview of the current knowledge of inflammasome biology and their role in health and disease.
Author(s): Virginie Pétrilli, Fabio Martinon (auth.), Isabelle Couillin, Virginie Pétrilli, Fabio Martinon (eds.)
Series: Progress in Inflammation Research
Edition: 1
Publisher: Springer Basel
Year: 2011
Language: English
Pages: 226
Tags: Immunology; Infectious Diseases; Cell Biology; Cytokines and Growth Factors; Enzymology
Front Matter....Pages i-xiii
Molecular Definition of Inflammasomes....Pages 1-16
Pyroptosis: A Caspase-1-Dependent Programmed Cell Death and a Barrier to Infection....Pages 17-36
Activation of the Inflammasome by Bacterial Pathogens....Pages 37-50
The Role of Inflammasomes in Viral Infection....Pages 51-64
Inflammasome Activation in Response to Eukaryotic Pathogens....Pages 65-83
Inflammasome Activation by Pathogenic Crystals and Particles....Pages 85-99
Inflammasome Activation by Danger Signals....Pages 101-121
Toll-Like Receptors and Inflammasomes....Pages 123-132
Inflammasome in the Skin....Pages 133-149
Cancer, Inflammasomes, and Adjuvanticity....Pages 151-163
Inflammasome and Lung Pathologies....Pages 165-182
Mechanisms of NLRP3 Inflammasome Activation in CAPS Patients....Pages 183-195
Activation and Regulation of the NLRP3 Inflammasome....Pages 197-208
Treatment of Inflammasome-Related Disorders....Pages 209-220
Back Matter....Pages 221-223
