It has long been known that aspects of behavior run in families; studies show that characteristics related to cognition, temperament, and all major psychiatric disorders are heritable. This volume offers a primer on understanding the genetic mechanisms of such inherited traits. It proposes a set of tools—a conceptual basis—for critically evaluating recent studies and offers a survey of results from the latest research in the emerging fields of cognitive genetics and imaging genetics. The chapters emphasize fundamental issues regarding the design of experiments, the use of bioinformatic tools, the integration of data from different levels of analysis, and the validity of findings, arguing that associations between genes and cognitive processes must be replicable and placed in a neurobiological context for validation. The Genetics of Cognitive Neuroscience aims to give the reader a working understanding of the influence of specific genetic variants on cognition, affective regulation, personality, and central nervous system disorders. With its emphasis on general methodological points, it will remain a valuable resource in a fast-evolving field. Contributors : Kristin L. Bigos, Katherine E. Burdick, Jingshan Chen, Aiden Corvin, Jeffrey L. Cummings, Ian J. Deary, Gary Donahoe, Eco J. C. de Geus, Jin Fan, Erika E. Forbes, John Fossella, Terry E. Goldberg, Ahmad R. Hariri, Lucas Kempf, Anil K. Malhotra, Venkata S. Mattay, Lauren M. McGrath. Kristin K. Nicodemus, Francesco Papaleo, Bruce F. Pennington, Michael I. Posner, Danielle Posthuma, John M. Ringman, Shelley D. Smith, Daniel R. Weinberger, Fengyu Zhang Issues in Clinical and Cognitive Neuropsychology series
Author(s): Terry E. Goldberg, Daniel R. Weinberger
Series: Issues in Clinical and Cognitive Neuropsychology
Edition: 1
Publisher: The MIT Press
Year: 2009
Language: English
Pages: 312
Contents......Page 8
Preface......Page 10
Introduction......Page 12
I Methodologies for Genetic Association Studies of Cognition......Page 14
1 Molecular Genetics and Bioinformatics......Page 16
2 Statistical Methods in Neuropsychiatric Genetics......Page 40
3 Animal Models of Genetic Effects on Cognition......Page 64
II Genetic Approaches to Individual Differences in Cognition and Affective Regulation......Page 108
4 The Genetics of Intelligence......Page 110
5 Candidate Genes Associated with Attention and Cognitive Control......Page 136
6 Genetics of Corticolimbic Function and Emotional Reactivity......Page 158
7 Genes Associated with Individual Differences in Cognitive Aging......Page 172
III Genetic Studies of Cognition and Treatment Response in Neuropsychiatric Disease......Page 188
8 Genetics of Dyslexia......Page 190
9 Cognitive Intermediate Phenotypes in Schizophrenia Genetics......Page 208
10 The Genetic Basis for the Cognitive Deterioration of Alzheimer’s Disease......Page 234
11 Pharmacogenetic Approaches to Neurocognition in Schizophrenia......Page 258
Contributors......Page 274
Index......Page 276
