This title provides an extremely helpful analysis of genes that may be associated with autoimmunity, and answers questions such as how these genes can be identified, and how the functions of the gene products can be elucidated.Incorporating data on disease-associated chromosomal loci that has been accumulated from inbred mice, the title:* descibes how some susceptibility loci may be common to many diseases, whereas others are relatively disease specific* discusses the importance of developing criteria for establishing the significance of these different categories of disease-associated loci.
Author(s): Novartis Foundation
Edition: 1
Year: 2005
Language: English
Pages: 260
GENETICS OF AUTOIMMUNITY......Page 3
Contents......Page 7
Participants......Page 9
Chair’s introduction......Page 11
Patterns of genetic variation in humans and mice......Page 12
Discussion......Page 18
Haplotype tagging in pharmacogenetics......Page 24
Discussion......Page 29
Multiple sclerosis: a haplotype association study......Page 41
Discussion......Page 49
Mapping genes for asthma and psoriasis......Page 56
Discussion......Page 62
Natural genetic variants influencing type 1 diabetes in humans and in the NOD mouse......Page 67
Discussion......Page 75
The importance of epistatic interactions in the development of autoimmunity......Page 86
Discussion......Page 98
Mapping autoimmune disease genes in humans: lessons from IBD and SLE......Page 104
Discussion......Page 117
A combined genetics and genomics approach to unravelling molecular pathways in coeliac disease......Page 123
Discussion......Page 144
Progress towards understanding the genetic pathogenesis of systemic lupus erythematosus......Page 155
Discussion......Page 170
A molecular dissection of lymphocyte unresponsiveness induced by sustained calcium signalling......Page 175
Discussion......Page 184
Genetic lesions in thymic T cell clonal deletion and thresholds for autoimmunity......Page 190
Discussion......Page 202
An autoimmune disease-associated CTLA4 splice variant lacking the B7 binding domain signals negatively in T cells......Page 210
Discussion......Page 222
Large-scale screens for cDNAs with in vivo activity......Page 229
Discussion......Page 239
Genomic mining of new genes and pathways in innate and adaptive immunity......Page 241
Discussion......Page 249
Index of contributors......Page 252
Subject index......Page 255
