Cancer will remain a global major health problem unless new diagnostic, prognostic, and management approaches are discovered to address both loss of life and quality of life. Here we summarize the general physiology, pathology, heterogeneity, and evolution of cancer, current status, limitations and challenges associated with prevention, incidence, treatment, survival, and mortality, as well as future directions with regards to solid tumors. Perspectives are provided on how to improve pre-clinical understandings, outcomes, and patient care. Further, this comprehensive, timely overview of the literature has educational value as part of an academic course, seminar, or as a supplementary text.
Author(s): Franklyn De Silva, Jane Alcorn
Publisher: CRC Press
Year: 2022
Language: English
Pages: 230
City: Boca Raton
Cover
Half Title
Title Page
Copyright Page
Dedication
Table of Contents
Preface
Acknowledgments
About the Authors
Chapter 1 Overview and Current Status of Cancer
Introduction
1.1 Multifaceted Aspects of Cancer
1.2 Types and Signs
Chapter 2 Diagnosis and Pathobiology
Introduction
2.1 Diagnosis
2.2 Evolutionary Paradigms and the Origin of Cancer
2.3 Heterogeneity and Dynamics of Cancer
2.4 Hallmarks of Cancer
2.5 Molecular Biology of Carcinogenesis
2.5.1 Genetic Underpinnings
2.5.2 Epigenetic Underpinnings
Chapter 3 Characteristics, Events, and Stages in Tumorigenesis
Introduction
3.1 Metastases and the Microenvironment
3.2 Cell-of-Origin, Disseminated and Circulating Tumor Cells, and Cancer Stem Cells
3.3 Tumor-Derived Exosomes and Particles
3.4 Oncogenic Viruses
3.5 Metabolic Syndrome and Cancer Metabolism
3.6 Convoluted Neovascularization
Chapter 4 Treatments and Challenges
Introduction
4.1 Chemotherapy, Radiotherapy, and Targeted Therapy
4.2 Immunotherapy
4.3 Drug Resistance and Cellular Reprogramming
4.4 Efficient Biomarkers
4.5 The Role of Nutraceuticals and Natural Products
4.6 Physiologically Relevant Nutrikinetics and Nutridynamics
Chapter 5 Additional Remarks, Perspectives, and Conclusions
References
Index
