The book The DNA Damage Response: Implications on Cancer Formation and Treatment brings together a great collection of review articles. The articles have been written by a group of experts who have a deep knowledge of the recent advances in the fields of DNA damage signalling and repair and their implications in carcinogenesis.
The book is divided into chapters that deal with the elaborate surveillance system and repair mechanisms used by cells to suppress mutagenic lesions to avoid cancer. It provides snapshots of:
* current understanding of DNA damage signalling,
* cell cycle checkpoints,
* some of the major DNA repair pathways,
* functional links between DNA damage,
* genomic instability and cancer,
* implications of DNA damage for the development of new treatment modalities for cancer.
Author(s): Daniel Durocher (auth.), Kum Kum Khanna, Yosef Shiloh (eds.)
Edition: 1
Publisher: Springer Netherlands
Year: 2009
Language: English
Pages: 449
Tags: Cancer Research; Oncology; Human Genetics; Immunology; Neurosciences
Front Matter....Pages i-xi
DNA Damage Sensing and Signaling....Pages 1-24
Signaling at Stalled Replication Forks....Pages 25-45
An Oncogene-Induced DNA Replication Stress Model for Cancer Development....Pages 47-63
Cellular Responses to Oxidative Stress....Pages 65-79
Cell Cycle Regulation and DNA Damage....Pages 81-107
Chromatin Modifications Involved in the DNA Damage Response to Double Strand Breaks....Pages 109-131
Telomere Metabolism and DNA Damage Response....Pages 133-156
DNA Double Strand Break Repair: Mechanisms and Therapeutic Potential....Pages 157-177
DNA Base Excision Repair: A Recipe for Survival....Pages 179-208
DNA Damage Tolerance and Translesion Synthesis....Pages 209-234
Nucleotide Excision Repair: from DNA Damage Processing to Human Disease....Pages 235-259
Chromosomal Single-Strand Break Repair....Pages 261-284
Mouse Models of DNA Double Strand Break Repair Deficiency and Cancer....Pages 285-305
Cancer Biomarkers Associated with Damage Response Genes....Pages 307-330
Linking Human RecQ Helicases to DNA Damage Response and Aging....Pages 331-347
Single-Stranded DNA Binding Proteins Involved in Genome Maintenance....Pages 349-366
The Fanconi anemia-BRCA Pathway and Cancer....Pages 367-414
BRCA1 and BRCA2: Role in the DNA Damage Response, Cancer Formation and Treatment....Pages 415-443
Back Matter....Pages 445-449
