Serving the needs of pigment cell biologists, cellular physiologists, developmental geneticists, researchers interested in melanoma and more, this new book showcases a blend of new technologies and new insights in the field of pigmantary genetics of mice, with comparative information on other animals. Graduate students can learn here the terminology and scope of the field, and animal fanciers can discover the genetics behind common color variants of mammals. The book is hailed for being written by four of the premier scientists in the field. These authors aim to present the molecular /cellular work in the context of phenotype and the interacting functions of genes that direct the development and function of one biological system. For other researchers, the depth of genetic knowledge on the pigmantary system makes it a valuable model for the study of other systems.
Author(s): M. Lynn Lamoreux, Veronique Delmas, Lionel Larue, Dorothy Bennett
Edition: 1
Publisher: Wiley-Blackwell
Year: 2010
Language: English
Pages: 312
The Colors of Mice......Page 5
Contents......Page 7
Preface......Page 9
Acknowledgments......Page 11
Statement regarding the use of pictures......Page 12
Statement regarding nomenclature......Page 14
Part I Introduction to the Pigmentary System......Page 15
1.1 Introduction......Page 17
1.2 Colors of vertebrate animals......Page 18
1.4 The epidermal melanin unit......Page 26
1.5 Mammalian hair......Page 27
1.6 Melanosome biogenesis and translocation......Page 28
1.8 Hair growth......Page 29
1.9 Hair growth cycles......Page 31
1.11 Pigment cells in culture......Page 32
1.12 Conclusion......Page 33
Appendix: color loci of the mouse......Page 34
Part II The Pigmentary Loci......Page 63
2.1 Defects of normal melanocyte development: white spotting and graying with age......Page 65
2.2 Defects in normal melanosome development: albinism......Page 66
2.3 Transport of melanosomes to other cells: the ‘dilute’ phenotype......Page 67
2.4 Pigment-type switching: from eumelanogenesis to pheomelanogenesis......Page 68
3 White Spotting and Progressive Graying......Page 71
3.1 Definitions and general background......Page 72
3.2 Pigment-cell development: developmental biology......Page 76
3.3 Cellular signaling pathways for melanocytes......Page 85
3.4 Pigment phenotypes and the classical white-spotting genes......Page 102
3.5 The head, heart, ears, and eyes......Page 141
4 'Albinism' and the Failure of Normal Melanosome Maturation......Page 146
4.1 Background......Page 147
4.2 The melanosomal matrix......Page 154
4.3 The enzymes that catalyze melanogenesis......Page 160
4.4 Membrane proteins that regulate the internal milieu of the melanosome......Page 167
4.5 Protein processing and routing to the maturing melanosome......Page 170
4.6 Melanosome transport......Page 185
5 Pigment-Type Switching......Page 191
5.1 Introduction......Page 192
5.2 Yellow phenotypes......Page 198
5.3 Melanin pigment......Page 203
5.4 Melanogenesis and the eumelanin/pheomelanin switch mechanism......Page 204
5.5 Signaling the switch mechanism at the cellular level......Page 206
5.6 Yellow genes......Page 208
Part III Technology and Resources......Page 221
6.1 Introduction......Page 223
6.2 Mouse transgenesis: generation of genetically engineered mice......Page 224
6.3 Coat-color transgenic mice......Page 233
6.4 The coat-color mutants generated by gene targeting......Page 238
6.5 Influence of the genetic background......Page 243
6.6 Conclusions......Page 244
7.1 Introduction......Page 246
7.2 Resources......Page 247
7.3 Other species......Page 249
References......Page 257
Index......Page 300
