The Collagens: Biochemistry and Pathophysiology

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This book describes every manner in which collagen is involved in normal anddisease-altered states of the various organs and systems. In the first part of the book the biochemical aspects of collagens are reviewed, including their structure, heterogeneity, syntheses, and degradation. The main part focuses on the involvement of collagen in bone, cartilage, tendon, muscle, heart, vessels, lungs, liver, skin, eye, ear, teeth, periodontal tissues, kidneys and reproductive, hemopoietic,and nervous systems. The influence of radiation and nutrition on collagen, the role of collagen in neoplasms, the hormonal control of its metabolism, immunobiology and the pharmacology of collagen are also described. The most important feature of the book is the comprehensive review of the medical aspects of collagen, from those known in detail to those only hypothesized including hereditary disorders affecting collagen and so-called collagen diseases. Each chapter reviewsknown or possible mechanisms of collagen involvement and changes in indices of collagen which can be measured in clinical practice to monitor these phenomena. The fact that collagen is involved into the pathophysiology of almost all organs and body systems means that physicians in almost all branches of medicine will find this book of great interest.

Author(s): Eugene J. Kucharz M.D., Ph.D. (auth.)
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 1992

Language: English
Pages: 430
Tags: Biochemistry, general; Orthopedics

Front Matter....Pages I-XVIII
Introduction: Historical Outline....Pages 1-3
Structure, Heterogeneity, and Distribution....Pages 5-29
Biosynthesis of Collagen....Pages 31-53
Degradation....Pages 55-67
Turnover and Regulation of Collagen Metabolism....Pages 69-76
Collagen in Development, Aging, and Phylogeny....Pages 77-86
Hormonal Regulation of Collagen Metabolism....Pages 87-105
Immunobiology of Collagen....Pages 107-112
Hereditary Disorders of Collagen....Pages 113-137
Collagen Diseases....Pages 139-147
Musculoskeletal System....Pages 149-175
Cardiovascular System....Pages 177-193
Respiratory System....Pages 195-202
The Liver....Pages 203-217
The Teeth and Periodontal Tissues....Pages 219-226
The Skin and Wound Healing....Pages 227-232
The Eye and The Ear....Pages 233-243
Urinary and Reproductive Systems....Pages 245-260
Collagen in the Nervous System....Pages 261-263
Collagen in Hematology....Pages 265-269
Collagen and Neoplasia....Pages 271-278
Effect of Nutrition....Pages 279-281
Effect of Ionizing Radiation....Pages 283-285
Pharmacological Control of Collagen Metabolism....Pages 287-310
Indices of Collagen Metabolism in Clinical Practice....Pages 311-313
Back Matter....Pages 315-430