Until recently, the cellular basis for sudden death, the Brugada Syndrome, has largely remained an unknown to modern arrhythmologists and cardiologists, particularly in the absence of any structural heart disease. Detailed observations of age-groups, especially the young, families and populations where sudden death frequently occurs, and improved understanding of its contributory factors and mechanisms are, however, showing the way forward.This addition to the Clinical Approaches to Tachyarrhythmias (CATA) Series, written by the investigators who discovered and probed the Brugada Syndrome, discusses the history, etiology, pathology and clinical manifestations of sudden death. From diagnosis, prognosis, to therapeutic approaches using the latest in cathater ablation techniques, electrophysiological surgery, and genetic appraisal, the work is a testimony to the author's investigation. Using clinical cases in Thailand and Laos, they further unravel the syndrome's molecular mechanisms, studying related syndromes, such as the long-QT syndrome, infant death, and arryhthmogenic right ventricular cardiomyopathy.By being informed of the electrophysiological abnormalities that contribute to familial and genetic diseases, physicians, cardiologists and all those who care for patients with cardiac arrhythmias will be better able to identify and treat patients in whom the Brugada Syndrome may strike next.
Author(s): Charles Antzelevitch, Pedro Brugada, Joseph Brugada, Ramon Brugada
Publisher: Wiley-Blackwell
Year: 2005
Language: English
Pages: 242
Tags: Медицинские дисциплины;Кардиология;
Contributors......Page 7
Preface......Page 11
Dedication......Page 13
CHAPTER 1 Brugada syndrome: overview......Page 15
CHAPTER 2 History of the Brugada syndrome......Page 37
CHAPTER 3 Biophysical analysis of mutant sodium channels in Brugada syndrome......Page 40
CHAPTER 4 Molecular genetics of the Brugada syndrome......Page 56
CHAPTER 5 Cellular mechanisms underlying the Brugada syndrome......Page 66
CHAPTER 6 Brugada syndrome: diagnostic criteria......Page 92
CHAPTER 7 Val ue of 12 lead electrocardiogram and derived methodologies in the diagnosis of Brugada disease......Page 101
CHAPTER 8 Brugada syndrome: relationship to other arrhythmogenic syndromes......Page 125
CHAPTER 9 STsegment elevation and sudden death in the athlete......Page 133
CHAPTER 10 Brugada syndrome: role of genetics in clinical practice......Page 144
CHAPTER 11 Genotype–phenotype relationship in the Brugada syndrome......Page 154
CHAPTER 12 Gender differences in Brugada syndrome......Page 163
CHAPTER 13 Predisposing factors......Page 171
CHAPTER 14 Acquired forms of Brugada syndrome......Page 180
CHAPTER 15 Atrial tachyarrhythmias in Brugada syndrome......Page 192
CHAPTER 16 Prognosis in individuals with Brugada syndrome......Page 198
CHAPTER 17 Treatment of Brugada syndrome with an implantable cardioverter defibrillator......Page 208
CHAPTER 18 Pharmacologic approach to therapy of Brugada syndrome: quinidine as an alternative to ICD therapy?......Page 216
CHAPTER 19 Potential for ablation therapy in patients with Brugada syndrome......Page 226
Index......Page 235
