There have been many impressive advances in our understanding of the pathogenesis of gastric adenocarcinoma, gastric MALT lymphoma, gastrointestinal stromal tumors of the stomach, and gastric carcinoid tumors over the years. "The Biology of Gastric Cancers," edited by Dr. Timothy Wang, Dr. James Fox and Dr. Andy Giraud, pays homage to the cutting edge concepts of cancer stem cells, tumor microenvironment, chronic inflammation, and genetic susceptibility to cancer and represents the very first volume devoted to the subject of the basic biology of gastric cancer. With an emphasis on animal models, but also considerable attention to human studies, host genetics and the role of bacterial factors and other environmental factors influencing the pathogenesis of gastric cancer, the topics presented in this book should be of interest to clinicians and investigators interested in gastrointestinal cancer, as well as basic investigators in related areas of cancer research. This body of work will hopefully stimulate clinical and translational studies that will advance early diagnosis and treatment of gastric tumors.
Author(s): Pelayo Correa, M. Constanza Camargo, M. Blanca Piazuelo (auth.), Timothy C. Wang, James G. Fox, Andrew S. Giraud (eds.)
Edition: 1
Publisher: Springer-Verlag New York
Year: 2009
Language: English
Commentary: 44914
Pages: 332
Tags: Cancer Research; Biomedicine general; Medical Microbiology; Human Genetics; Life Sciences, general
Front Matter....Pages i-xxii
Overview and Pathology of Gastric Cancer....Pages 1-24
Epidemiology of Gastric Cancer and Helicobacter pylori ....Pages 25-57
Diet and Gastric Cancer....Pages 59-89
MALT Lymphoma: Clinicopathologic Features and Molecular Pathogenesis....Pages 91-133
Gastrointestinal Stromal Tumors of Gastric Origin....Pages 135-163
Human Gastric Neuroendocrine Neoplasia: Current Pathologic Status....Pages 165-184
Gastric Neuroendocrine Neoplasia....Pages 185-216
Epstein-Barr Virus and Gastric Cancer....Pages 217-233
Role of Host Genetic Susceptibility in the Pathogenesis of Gastric Cancer....Pages 235-250
Cancer Genetics of Human Gastric Adenocarcinoma....Pages 251-283
Genomic and Proteomic Advances in Gastric Cancer....Pages 285-321
Animal Models of Gastric Carcinoma....Pages 323-359
Insights into the Development of Preneoplastic Metaplasia: Spasmolytic Polypeptide-Expressing Metaplasia and Oxyntic Atrophy....Pages 361-375
Deregulation of E-Cadherin in Precancerous Lesions and Gastric Cancer....Pages 377-388
Role of CagA in Helicobacter pylori Infection and Pathology....Pages 389-401
The Role of Helicobacter pylori Virulence Factors in Rodent and Primate Models of Disease....Pages 403-423
Host Immunity in the Development of Gastric Preneoplasia....Pages 425-447
Atrophy and Altered Mesenchymal—Epithelial Signaling Preceding Gastric Cancer....Pages 449-482
Genetic Models of Gastric Cancer in the Mouse....Pages 483-512
Prostaglandin and Transforming Growth Factor β Signaling in Gastric Cancer....Pages 513-540
REG Proteins and Other Growth Factors in Gastric Cancer....Pages 541-560
Role of Bone Marrow—Derived Cells in Gastric Adenocarcinoma....Pages 561-586
Stromal Cells and Tumor Microenvironment....Pages 587-600
Future Prospects for Helicobacter pylori Vaccination....Pages 601-620
Back Matter....Pages 621-646
