This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons.
This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease).
The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies.
Author(s): Rhian M. Touyz (ed.), Christian Delles (ed.)
Publisher: Springer
Year: 2019
Language: English
Pages: 503
City: Cham, Switzerland
Front Matter ....Pages I-XIX
Front Matter ....Pages 1-1
Anatomy and Pharmacology of Vessels (Simon Kennedy, Rhian M. Touyz)....Pages 3-11
Vascular Physiology (Delyth Graham)....Pages 13-22
Cell Biology of Vessels (Rheure Alves-Lopes, Rhian M. Touyz, Augusto C. Montezano)....Pages 23-30
Stem Cell Biology and the Cardiovascular System (Joanne C. Mountford, Kim A. Connelly)....Pages 31-44
The Lymphatic System (Giacomo Rossitto, Margaret Sneddon, Stanley G. Rockson)....Pages 45-57
Imaging the Vascular Wall: From Microscope to Virtual Reality (Craig J. Daly)....Pages 59-66
Clinical Cardiovascular Imaging (Aleksandra Radjenovic, Giles Roditi)....Pages 67-79
Front Matter ....Pages 81-81
Vascular Signaling (Karla B. Neves, Rhian M. Touyz)....Pages 83-91
Vasoactive Peptides: Renin-Angiotensin-Aldosterone System (Katrin Nather, Christopher M. Loughrey, Stuart A. Nicklin)....Pages 93-101
Aldosterone (Scott M. MacKenzie, Aurelie Nguyen Dinh Cat, Josie C. van Kralingen, Eleanor Davies)....Pages 103-115
Nitric Oxide (James Leiper)....Pages 117-126
Reactive Oxygen Species (Livia de Lucca Camargo, Rhian M. Touyz)....Pages 127-136
TGF-β in Vascular Pathobiology (Julian Tristan Schwartze, Emma Louise Low, Angela Claire Bradshaw)....Pages 137-148
MicroRNA and LncRNA in the Vascular System (Margaret D. Ballantyne, Katey J. Rayner, Duncan J. Stewart, Andrew H. Baker, Kenny Schlosser)....Pages 149-158
Microparticles and Exosomes in Cell-Cell Communication (Francisco J. Rios, Rhian M. Touyz, Augusto C. Montezano, Dylan Burger)....Pages 159-168
Front Matter ....Pages 169-170
Genomics of Hypertension (Sandosh Padmanabhan, Alisha Aman, Anna F. Dominiczak)....Pages 171-181
Endothelial Dysfunction (Heather Yvonne Small, Gemma Currie, Christian Delles)....Pages 183-192
Vascular Remodeling (Carmine Savoia)....Pages 193-201
Arterial Stiffness (Carmel M. McEniery, Kathleen Connolly)....Pages 203-213
Atherosclerosis (John Mercer, Tomasz J. Guzik)....Pages 215-228
Inflammation and Immunity in Vascular Diseases (Lucy McShane, Andrew P. Sage, Pasquale Maffia)....Pages 229-238
Diagnostic and Therapeutic Targeting of Inflammation (Tomasz J. Guzik)....Pages 239-246
Perivascular Adipose Tissue (Saad Javed, Mariam Alakrawi, Adam S. Greenstein)....Pages 247-258
Vascular Biology of Cancer Chemotherapeutic Drugs (Alan C. Cameron, Rhian M. Touyz, Ninian N. Lang)....Pages 259-268
Coronary Microvascular Disease (Novalia Purnama Sidik, Peter McCartney, Colin Berry)....Pages 269-273
Cerebral Small Vessel Disease and Vascular Cognitive Impairment: Preclinical Aspects (Anne M. Dorrance, Bana Abolibdeh, Janice M. Diaz-Otero)....Pages 275-285
Ethnicity and Cardiovascular Disease (Aletta E. Schutte)....Pages 287-295
Front Matter ....Pages 297-298
Epidemiology of Vascular Diseases (Paul Welsh, Stamatina Iliodromiti)....Pages 299-306
Healthy Vascular Ageing and Early Vascular Ageing (Gemma Currie, Peter M. Nilsson)....Pages 307-318
Biomarkers of Cardiovascular Disease (Susana Ravassa, Christian Delles, Gemma Currie, Javier Díez)....Pages 319-330
Hypertension (Alan C. Cameron, Anna F. Dominiczak, Rhian M. Touyz)....Pages 331-341
Diabetic Retinopathy (Jennifer L. Wilkinson-Berka, Christolyn Raj)....Pages 343-354
Ischaemic Heart Disease (Damien Collison, Keith G. Oldroyd)....Pages 355-363
Pre-eclampsia (David Carty)....Pages 365-372
Stable Coronary Syndromes (David Corcoran, Thomas J. Ford, Colin Berry)....Pages 373-381
Heart Failure with Reduced Ejection Fraction (Alice M. Jackson, Pardeep S. Jhund)....Pages 383-395
Heart Failure with Preserved Ejection Fraction (Christopher J. Rush, Mark C. Petrie)....Pages 397-408
Renal Disease (Patrick B. Mark, Laura Denby)....Pages 409-417
Obesity (Jennifer Logue, Naveed Sattar, Dilys Freeman)....Pages 419-427
Diabetes and Vascular Disease (John R. Petrie, Ian P. Salt)....Pages 429-437
Pulmonary Hypertension (M. R. MacLean, C. Church, A. MacKenzie, G. Jayasekera, K. Mair)....Pages 439-447
Cerebral Small Vessel Disease and Vascular Cognitive Impairment (Terence J. Quinn, Stephen Makin, Fergus Doubal, Julie Staals)....Pages 449-459
Stroke (Aisling McFall, Jesse Dawson, Lorraine M. Work)....Pages 461-472
Peripheral Vascular Disease (Jason Ramsingh, David Kingsmore)....Pages 473-483
Vascular Malformations and Tumours (David A. Koppel, Jaime Grant)....Pages 485-499
Back Matter ....Pages 501-503
