THE encyclopedic guide to hepatology – for consultation by clinicians and basic scientistsPreviously the Oxford Textbook of Clinical Hepatology, this two-volume textbook is now with Blackwell Publishing. It covers basic, clinical and translational science (converting basic science discoveries into the practical applications to benefit people).Edited by ten leading experts in the liver and biliary tract and their diseases, along with outstanding contributions from over 200 international clinicians, this text has global references, evidence and extensive subject matter – giving you the best science and clinical practice discussed by the best authors.It includes unique sections on:Symptoms and signs in liver disease Industrial diseases affecting the liver The effects of diseases of other systems on the liver The effects of liver diseases on other systemsIt’s bigger and more extensive than other books and discusses new areas in more depth such as stem cells, genetics, genomics, proteomics, transplantation, mathematics and much more.Plus, it comes with a fully searchable CD ROM of the entire content.Click here to view a sample chapter on the liver and coagulation
Author(s): Juan Rodes, Jean-Pierre Benhamou, Andres Blei, Juerg Reichen, Mario Rizzetto
Edition: 3
Publisher: Wiley-Blackwell
Year: 2007
Language: English
Pages: 2239
Cover......Page 1
Textbook of Hepatology: From Basic Science to Clinical Practice......Page 2
Copyright......Page 5
Contributors......Page 12
Foreword......Page 22
Preface to the third edition......Page 23
Preface to the first edition......Page 24
1 Architecture of the liver......Page 25
1.1 Macroscopic anatomy of the liver......Page 26
1.2 Liver and biliary tract histology......Page 32
1.3 Ultrastructure of the hepatocyte......Page 43
1.4 Liver sinusoidal endothelial cells......Page 52
1.5 Kupffer cells......Page 59
1.6 The hepatic stellate cell......Page 66
1.7 Biliary epithelial cells......Page 75
1.8 Hepatic stem cells......Page 81
1.9 Embryology of the liver and intrahepatic biliary tract......Page 88
2 Functions of the liver......Page 95
2.1 Hepatic circulation......Page 96
2.2 Functions of the liver......Page 110
2.3 Metabolism......Page 150
2.4 Synthetic function......Page 271
2.5 Regulation of the liver cell mass......Page 295
2.6 Excretion......Page 311
2.7 Immunology of the liver......Page 333
3 Basic concepts in pathobiology......Page 353
3.1 Hepatocyte apoptosis and necrosis......Page 354
3.2 Ischaemia–reperfusion injury to the liver......Page 367
3.3 Genetics and liver diseases......Page 375
3.4 Cellular cholestasis......Page 403
3.5 Oncogenes and tumour suppressor genes......Page 410
3.6 Genomics, gene arrays and proteomics in the study of liver disease......Page 417
4 Pathology......Page 440
4.1 Histological features......Page 441
4.2 Classifications, scoring systems and morphometry in liver pathology......Page 451
5 Investigation of hepatobiliary disease......Page 459
5.1 Signs and symptoms of liver disease......Page 460
5.2 Biochemical investigations in the management of liver disease......Page 468
5.3 Hepatic removal kinetics: importance for quantitative measurements of liver function......Page 485
5.4 Immunological investigations in liver diseases......Page 496
5.5 Biopsy and laparoscopy......Page 506
5.6 Imaging of the liver......Page 517
5.7 Interventional radiology in hepatobiliary diseases......Page 566
5.8 Positron emission tomography of the liver......Page 578
5.9 Splanchnic haemodynamic investigations......Page 584
5.10 The Cochrane Hepatobiliary Group......Page 589
6 Cirrhosis......Page 597
6.1 The evolution of cirrhosis......Page 598
6.2 Cellular and molecular pathobiology of liver fibrosis and its pharmacological intervention......Page 605
6.3 Clinical and diagnostic aspects of cirrhosis......Page 619
7 Portal hypertension and its complications......Page 635
7.1 Anatomy of the portal venous system in portal hypertension......Page 636
7.2 Pathogenesis of portal hypertension......Page 643
7.3 Clinical manifestations and management of bleeding episodes in cirrhotics......Page 653
7.4 Haemodynamic assessment of portal hypertension......Page 671
7.5 Pathogenesis, diagnosis and treatment of ascites in cirrhosis......Page 679
7.6 Hepatorenal syndrome......Page 724
7.7 Pulmonary complications of portal hypertension......Page 733
7.8 Hepatic encephalopathy......Page 741
7.9 Bacterial infections in portal hypertension......Page 774
7.10 Hypersplenism......Page 784
8 Congenital hepatic fibrosis and non-parasitic cystic lesions of the liver and bile ducts......Page 792
8.1 Congenital conditions......Page 793
8.2 Acquired conditions......Page 822
9 Viral infections of the liver......Page 830
9.1 Viral hepatitis......Page 831
9.2 Systemic virosis producing hepatitis......Page 967
9.3 Human immunodeficiency virus and the liver......Page 984
9.4 Exotic virus infections of the liver......Page 998
10 Other infections of the liver......Page 1009
10.1 Bacterial, rickettsial and spirochaetal infections......Page 1010
10.2 Fungal infections affecting the liver......Page 1020
10.3 Protozoal infections affecting the liver......Page 1029
10.4 Helminthiasis......Page 1049
11 Immune disorders of the liver......Page 1077
11.1 Primary biliary cirrhosis......Page 1078
11.2 Autoimmune hepatitis......Page 1096
11.3 Sclerosing cholangitis......Page 1110
11.4 Vanishing bile duct syndrome......Page 1118
11.5 Overlap syndromes......Page 1127
12 Alcoholic liver disease......Page 1134
12.1 Epidemiological aspects of alcoholic liver disease......Page 1135
12.2 Ethanol metabolism and pathogenesis of alcoholic liver injury......Page 1141
12.3 Pathology of alcoholic liver disease......Page 1154
12.4 Alcoholic liver disease: natural history, diagnosis, clinical features, evaluation, prognosis and management......Page 1163
12.5 Management of the alcoholic patient, including alcoholism and extrahepatic manifestations......Page 1185
13 Hepatic non-alcoholic steatosis......Page 1198
13 Non-alcoholic fatty liver and non-alcoholic steatohepatitis......Page 1199
14 Toxic liver injury......Page 1213
14.1 Drug-induced liver injury......Page 1214
14.2 Toxic liver injury......Page 1272
14.3 Hepatic injury due to physical agents......Page 1280
14.4 Hepatic toxicity induced by herbal medicines......Page 1284
15 Acute liver failure......Page 1292
15 Acute liver failure and related syndromes......Page 1293
16 Genetic and metabolic diseases......Page 1315
16.1 Wilson’s disease......Page 1316
16.2 Haemochromatosis......Page 1324
16.3 Alpha-1-antitrypsin deficiency and related disorders......Page 1331
16.4 The liver in cystic fibrosis......Page 1337
16.5 Human hereditary porphyrias......Page 1344
16.6 Hyperbilirubinaemia......Page 1353
16.7 The liver in intracellular and extracellular lipidosis......Page 1361
16.8 Glycogen storage diseases......Page 1371
16.9 Mitochondriopathies......Page 1378
16.10 Genetic cholestatic diseases......Page 1384
17 Vascular diseases......Page 1390
17.1 Hepatic artery diseases......Page 1391
17.2 Obstruction of the portal vein......Page 1395
17.3 Disorders of the hepatic veins and hepatic sinusoids......Page 1403
17.4 Congenital vascular malformations......Page 1418
18 Tumours of the liver......Page 1424
18.1 Benign hepatic tumours......Page 1425
18.2 Malignant tumours......Page 1435
18.3 Metastatic tumours......Page 1462
19 Biliary tract diseases......Page 1477
19.1 Intrahepatic cholestasis......Page 1478
19.2 Extrahepatic biliary obstruction: systemic effects, diagnosis and management......Page 1498
19.3 Gallstone disease......Page 1515
19.4 Cholangitis and biliary tract infections......Page 1538
19.5 Haemobilia......Page 1547
19.6 Biliary dyskinesia......Page 1558
19.7 Benign biliary tumours......Page 1570
19.8 Gallbladder carcinoma......Page 1572
19.9 Cholangiocarcinoma......Page 1580
20 The liver in diseases of other systems......Page 1603
20.1 The liver in cardiovascular disease......Page 1604
20.2 The liver in lung diseases......Page 1611
20.3 The effect of gastrointestinal diseases on the liver and biliary tract......Page 1617
20.4 Total parenteral nutrition-related liver disease......Page 1629
20.5 The effect of skin diseases on the liver......Page 1637
20.6 The liver in urogenital diseases......Page 1648
20.7 The effect of haematological and lymphatic diseases on the liver......Page 1657
20.8 The liver in graft-vs.-host disease......Page 1666
20.9 The effect of endocrine diseases on liver function......Page 1675
20.10 Musculoskeletal diseases and the liver......Page 1689
20.11 Amyloidosis......Page 1697
20.12 Hepatic granulomas......Page 1704
21 The impact of liver disease on other systems......Page 1713
21.1 The effect of liver disease on the cardiovascular system......Page 1714
21.2 The effect of liver disease on the endocrine system......Page 1725
21.3 Haematological abnormalities in liver disease......Page 1760
21.4 Haemostasis in liver disease......Page 1773
21.5 The effect of liver disease on the gastrointestinal tract......Page 1791
21.6 The effect of liver disease on the skin......Page 1797
21.7 The effect of liver disease on the urogenital tract......Page 1808
21.8 The nervous system in liver disease......Page 1815
21.9 The effect of liver disease on bone......Page 1822
21.10 The effect of liver disease on nutritional status and energy metabolism......Page 1829
22 The liver in specific settings......Page 1836
22.1 Paediatric liver diseases......Page 1837
22.2 Liver diseases in the elderly......Page 1862
22.3 Liver diseases and pregnancy......Page 1871
23 The management of liver diseases......Page 1888
23.1 The general management of liver diseases......Page 1889
23.2 Nutritional aspects of liver and biliary disease......Page 1895
23.3 Prescribing drugs in liver disease......Page 1902
23.4 Management of pretransplant patients......Page 1912
24 Surgery, anaesthesia and the liver......Page 1921
24.1 General surgical aspects and the risks of liver surgery in patients with hepatic disease......Page 1922
24.2 Anaesthesia and liver disease......Page 1927
24.3 Postoperative jaundice......Page 1934
24.4 Hepatobiliary trauma......Page 1942
25 Liver transplantation......Page 1951
25.1 Surgical techniques......Page 1952
25.2 Liver transplantation: indications, contraindications and results......Page 1971
25.3 The perioperative care and complications of liver transplantation......Page 1983
25.4 Immunosuppression......Page 1990
25.5 Recurrent disease and management in liver transplantation......Page 1997
25.6 Post-transplantation management and complications......Page 2006
25.7 Liver transplantation and quality of life......Page 2014
25.8 Emerging therapies......Page 2019
26 Mathematics in hepatology......Page 2040
26.1 Models in clinical hepatology......Page 2041
26.2 Outcomes research in hepatology......Page 2051
26.3 Meta-analysis......Page 2059
26.4 Economic considerations in hepatology......Page 2066
26.5 Development of the liver interactome: mapping the regulatory networks......Page 2074
27 Appendices......Page 2082
27.1 Geographic distribution of infections causing liver disease......Page 2083
27.2 Liver injury in man ascribed to non-drug chemicals and natural toxins......Page 2089
27.3 Rare diseases with hepatic abnormalities......Page 2106
Index......Page 2145
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