Telomeres and telomerase are the pivotal players that destine cellular senescence and immortalization. Telomere shortening due to "End-replication problem" in each cell cycle is a universal phenomenon for all eukaryotic cells with linear chromosomes. Its compensation by telomerase is also common from yeast to human. However, the length of telomeres, distribution of telomerase positive cells, and consequence of telomerase inhibition are different among species. "Telomeres and Telomerase in Cancers", edited by Keiko Hiyama, focuses on "Human" telomeres and telomerase, from basic biology and hypothesis in human normal cells and cancer cells to clinical application as diagnostic tools and therapeutic targets in anti-cancer strategy. Cutting-edge experimental protocols for their evaluation are also included. This coverage will enable medical oncologists and students as well as basic researchers to capture the up-to-date entire picture of human telomeres and telomerase in cancer.
Author(s): Keiko Hiyama, Eiso Hiyama, Jerry W. Shay (auth.), Keiko Hiyama (eds.)
Series: Cancer Drug Discovery and Development
Edition: 1
Publisher: Humana Press
Year: 2009
Language: English
Commentary: 35927
Pages: 380
Tags: Cancer Research; Oncology; Pharmacology/Toxicology
Front Matter....Pages i-xii
Telomeres and Telomerase in Humans....Pages 3-21
Telomere-Binding Proteins in Humans....Pages 23-46
Regulation of Telomerase Through Transcriptional and Posttranslational Mechanisms....Pages 47-85
Telomere Dysfunction and the DNA Damage Response....Pages 87-125
Alternative Lengthening of Telomeres in Human Cells....Pages 127-148
Mouse Model: Telomeres and Telomerase in Stem Cell and Cancer....Pages 149-167
Role of Telomeres and Telomerase in Cancer....Pages 171-180
Diagnostic Value I: Solid Tumors....Pages 181-210
Diagnostic Value II: Hematopoietic Malignancies....Pages 211-224
Therapeutic Targets and Drugs I: Telomerase and Telomerase Inhibitors....Pages 225-249
Therapeutic Targets and Drugs II: G-Quadruplex and G-Quadruplex Inhibitors....Pages 251-280
Therapeutic Targets and Drugs III: Tankyrase 1, Telomere-Binding Proteins, and Inhibitors....Pages 281-291
Therapeutic Targets and Drugs IV: Telomerase-Specific Gene and Vector-Based Therapies for Human Cancer....Pages 293-312
Protocol I: Telomerase Activity and Telomerase Expression....Pages 315-335
Protocol II: Importance and Methods of Telomere G-Tail Length Quantification....Pages 337-350
Protocol III: Detection of Alternative Lengthening of Telomeres....Pages 351-364
Back Matter....Pages 365-373
