This first thematic issue, of the Advances in Immunology series, highlights the remarkable new insights into the mechanisms that govern development and function of T cell lineages. Recent developments in the understanding of the genetic and epigenetic mechanisms that regulate development of the two major T cell lineages will have a fundamental impact on a number of research fields -immunology, cell biology, hematology and stem cell research. All of these groups have a vested interest in comprehending issues such as stem cell self renewal, progenitor plasticity, lineage commitment and cellular identity. Immunologists have a special interest in the mechanisms that allow selection of a T cell repertoire whose members integrate genetic information for T cell receptor, co-receptor and specialized immunologic function, since this process lies at the core of adaptive immunity. T Cell Subsets is a timely and invaluable review for immunologists, cell biologists hematologists and stem cell researchers
Author(s): Harvey Cantor, Laurie Glimcher, and Frederick W. Alt (Eds.)
Series: Advances in Immunology 83
Edition: 1
Publisher: Academic Press
Year: 2004
Language: English
Pages: 1-304
Content:
Contributors
Pages ix-x
Introduction
Pages xi-xiv
Lineage Commitment and Developmental Plasticity in Early Lymphoid Progenitor Subsets Original Research Article
Pages 1-54
David Traver, Koichi Akashi
The CD4⧸CD8 Lineage Choice: New Insights into Epigenetic Regulation during T Cell Development Original Research Article
Pages 55-89
Ichiro Taniuchi, Wilfried Ellmeier, Dan R Littman
CD4⧸CD8 Coreceptors in Thymocyte Development, Selection, and Lineage Commitment: Analysis of the CD4⧸CD8 Lineage Decision Original Research Article
Pages 91-131
Alfred Singer, Remy Bosselut
Development and Function of T Helper 1 Cells Original Research Article
Pages 133-162
Anne O'Garra, Douglas Robinson
Th2 Cells: Orchestrating Barrier Immunity Original Research Article
Pages 163-189
Daniel B Stetson, David Voehringer, Jane L Grogan, Min Xu, R.Lee Reinhardt, Stefanie Scheu, Ben L Kelly, Richard M Locksley
Generation, Maintenance, and Function of Memory T Cells Original Research Article
Pages 191-231
Patrick R Burkett, Rima Koka, Marcia Chien, David L Boone, Averil Ma
CD8+ Effector Cells Original Research Article
Pages 233-252
Pierre A Henkart, Marta Catalfamo
An Integrated Model of Immunoregulation Mediated by Regulatory T Cell Subsets Original Research Article
Pages 253-288
Hong Jiang, Leonard Chess
Index
Pages 289-300
