Post-traumatic stress disorder (PTSD) arises from the experience of severe stressors and trauma. The disorder is characterized by recurrent recall of intrusive memories to the event, nightmares with insomnia, emotional numbing, hyperarousal, which are all long-lasting and relatively resistant to therapy. The focus of this book is on the question of how stress hormones are involved in PTSD. Recent evidence suggests that a dysregulation in stress hormones promotes the precipitation of PTSD and that correction of these hormones may ameliorate the disorder. This book combines state-of-the-art basic research on stress hormones from gene to behaviour with clinical research demonstrating the progress in understanding via imaging techniques, genetics, vulnerable phenotypes and co-morbidity with other disorders and physical illness.
Author(s): E. Ronald De Kloet, Melly S. Oitzl and Eric Vermetten (Eds.)
Series: Progress in Brain Research 167
Edition: 1
Publisher: Elsevier Science
Year: 2007
Language: English
Commentary: 179517
Pages: 1-320
Content:
List of contributors
Pages v-viii
Preface
Pages ix-xi
E. Ronald de Kloet, Melly S. Oitzl, Eric Vermetten
Acknowledgements
Page xiii
Stress-induced changes in hippocampal function Review Article
Pages 3-15
Marian Joëls, Harm Krugers, Henk Karst
Glucocorticoids, developmental ‘programming’ and the risk of affective dysfunction Review Article
Pages 17-34
Jonathan R. Seckl
Amygdala modulation of memory-related processes in the hippocampus: potential relevance to PTSD Review Article
Pages 35-51
M.M. Tsoory, R.M. Vouimba, I. Akirav, A. Kavushansky, A. Avital, G. Richter-Levin
Commentary: Neuroendocrine basis Review Article
Pages 53-62
E.R. de Kloet
Mice that under- or overexpress glucocorticoid receptors as models for depression or posttraumatic stress disorder Review Article
Pages 65-77
Sabine Chourbaji, Miriam A. Vogt, Peter Gass
Adrenal stress hormones, amygdala activation, and memory for emotionally arousing experiences Review Article
Pages 79-97
Benno Roozendaal, Areg Barsegyan, Sangkwan Lee
Adult neurogenesis and systemic adaptation: animal experiments and clinical perspectives for PTSD Review Article
Pages 99-109
Noriko U. Takemura, Nobumasa Kato
Commentary: Behavioral phenotype Review Article
Pages 111-117
Melly S. Oitzl
Transgenerational transmission of cortisol and PTSD risk Review Article
Pages 121-135
Rachel Yehuda, Linda M. Bierer
Early care experiences and HPA axis regulation in children: a mechanism for later trauma vulnerability Review Article
Pages 137-149
Megan R. Gunnar, Karina M. Quevedo
The functional neuroanatomy of PTSD: a critical review Review Article
Pages 151-169
Israel Liberzon, Chandra Sekhar Sripada
Structural and functional plasticity of the human brain in posttraumatic stress disorder Review Article
Pages 171-186
J. Douglas Bremner, Bernet Elzinga, Christian Schmahl, Eric Vermetten
Commentary: biological findings in PTSD — too much or too little? Review Article
Pages 187-199
Arieh Y. Shalev, Ronen H. Segman
Models of PTSD and traumatic stress: the importance of research “from bedside to bench to bedside” Review Article
Pages 203-215
Robert J. Ursano, He Li, Lei Zhang, Chris J. Hough, Carol S. Fullerton, David M. Benedek, Thomas A. Grieger, Harry C. Holloway
What is it that a neurobiological model of PTSD must explain? Review Article
Pages 217-228
Chris R. Brewin
Post-traumatic stress disorder in somatic disease: lessons from critically ill patients Review Article
Pages 229-237
Gustav Schelling
Glucocorticoid-induced reduction of traumatic memories: implications for the treatment of PTSD Review Article
Pages 239-247
Dominique J.-F. de Quervain
Commentary: synthesis and perspectives Review Article
Pages 249-254
R.K. Pitman
Strain specific fear behaviour and glucocorticoid response to aversive events: modelling PTSD in mice Review Article
Pages 257-261
V. Brinks, E.R. de Kloet, M.S. Oitzl
Interaction of endogenous cortisol and noradrenaline in the human amygdala Review Article
Pages 263-268
Anda H. van Stegeren, Oliver T. Wolf, Walter Everaerd, Serge A.R.B. Rombouts
Corticosteroid hormones, synaptic strength and emotional memories: corticosteroid modulation of memory — a cellular and molecular perspective Review Article
Pages 269-271
Olof Wiegert, Marian Joëls, Harm J. Krugers
Does trauma cause lasting changes in HPA-axis functioning in healthy individuals? Review Article
Pages 273-275
Ellen R. Klaassens, Tineke van Veen, Frans G. Zitman
Need for alternative ways of phenotyping of mood, anxiety, and somatoform disorders in biological research Review Article
Pages 277-280
G. Veen, I.M. van Vliet, R.H. de Rijk, F.G. Zitman
The HPA-axis and immune function in burnout Review Article
Pages 281-285
Paula M.C. Mommersteeg, Cobi J. Heijnen, Annemieke Kavelaars, Lorenz J.P. van Doornen
Elevated plasma corticotrophin-releasing hormone levels in veterans with posttraumatic stress disorder Review Article
Pages 287-291
C.S. de Kloet, E. Vermetten, E. Geuze, E.G.W.M. Lentjes, C.J. Heijnen, G.K. Stalla, H.G.M. Westenberg
Precuneal activity during encoding in veterans with posttraumatic stress disorder Review Article
Pages 293-297
Elbert Geuze, Eric Vermetten, Carien S. de Kloet, Herman G.M. Westenberg
Posttraumatic stress disorder with secondary psychotic features: neurobiological findings Review Article
Pages 299-302
Mario H. Braakman, Frank A.M. Kortmann, Wim van den Brink, Robbert J. Verkes
Neuroendocrine dysregulations in sexually abused children and adolescents: a systematic review Review Article
Pages 303-306
I.A.E. Bicanic, M. Meijer, G. Sinnema, E.M. van de Putte, M. Olff
Volume of discrete brain structures in complex dissociative disorders: preliminary findings Review Article
Pages 307-310
T. Ehling, E.R.S. Nijenhuis, A.P. Krikke
Epilogue Review Article
Pages 311-313
Eric Vermetten
Subject Index
Pages 315-320
