The potential of stem cells for healing and disease prevention in all fields of medicine is tremendous and has revolutionized the high-tech biomedical research. In this book, many of the most prominent researchers discuss the challenging topics of stem cell engineering, for example: Ethical issues of stem cell research; technological challenges, stem cell growth and differentiation, therapeutic applications, bioreactors and bioprocesses, high throughput and microfluidic screening platforms, stem cell identification and sorting, intercellular signaling and engineered niches, novel approaches for embryonic and adult stem cell growth and differentiation, stem cells and drug discovery, screening platforms. Stem Cell Engineering offers valuable background and reference for both the public and professionals including industrial staffers, faculty, researchers, engineers, students and scientific journalists.
Author(s): Ilya Digel, Aysegül Temiz Artmann (auth.), Gerhard M. Artmann, Stephen Minger, Jürgen Hescheler (eds.)
Edition: 1
Publisher: Springer-Verlag Berlin Heidelberg
Year: 2011
Language: English
Pages: 547
Tags: Biomedical Engineering; Cell Biology; Biotechnology
Front Matter....Pages i-xli
Front Matter....Pages 1-1
The Emperor’s New Body: Seeking for a Blueprint of Limb Regeneration in Humans....Pages 3-37
Front Matter....Pages 39-39
Engineering the Stem Cell Niche and the Differentiative Micro- and Macroenvironment: Technologies and Tools for Applying Biochemical, Physical and Structural Stimuli and Their Effects on Stem Cells....Pages 41-59
Differentiation Potential of Adult Human Mesenchymal Stem Cells....Pages 61-77
The Potential of Selectively Cultured Adult Stem Cells Re-implanted in Tissues....Pages 79-117
Enhanced Cardiac Differentiation of Mouse Embryonic Stem Cells by Electrical Stimulation....Pages 119-141
The Therapeutic Potential of ES-Derived Haematopoietic Cells....Pages 143-158
Genetic Modification of Human Embryonic and Induced Pluripotent Stem Cells: Viral and Non-viral Approaches....Pages 159-179
The Immune Barriers of Cell Therapy with Allogenic Stem Cells of Embryonic Origin....Pages 181-197
Reponses of Mesenchymal Stem Cells to Varying Oxygen Availability In Vitro and In Vivo....Pages 199-211
Endothelial Progenitor Cells and Nitric Oxide: Matching Partners in Biomedicine....Pages 213-245
Skeletal Stem Cells and Controlled Nanotopography....Pages 247-258
Front Matter....Pages 259-259
Cells and Vascular Tissue Engineering....Pages 261-295
Endothelial Progenitor Cells for Vascular Repair....Pages 297-320
Regenerating Tubules for Kidney Repair....Pages 321-344
Stem Cells in Tissue Engineering and Cell Therapies of Urological Defects....Pages 345-362
Bio-synthetic Encapsulation Systems for Organ Engineering: Focus on Diabetes....Pages 363-381
Stem Cell Engineering for Regeneration of Bone Tissue....Pages 383-399
Front Matter....Pages 401-401
Building, Preserving, and Applying Extracellular Culture Integrity Using New Cell Culture Methods and Surfaces....Pages 403-415
Fabrication of Modified Extracellular Matrix for the Bone Marrow-Derived Mesenchymal Stem Cell Therapeutics....Pages 417-434
Neural Stem Cells: From Cell Fate and Metabolic Monitoring Toward Clinical Applications....Pages 435-455
Front Matter....Pages 401-401
Adult Stem Cells in Drug Discovery....Pages 457-471
Embryonic Stem Cells as a Tool for Drug Screening and Toxicity Testing....Pages 473-500
Embryonic Stem Cells: A Biological Tool to Translate the Mechanisms of Heart Development....Pages 501-520
Back Matter....Pages 521-547
