This is the first book in the field of mouse genetics to provide comprehensive and standardized methods for the characterization of laboratory mice. The editor is Director of the German Mouse Clinic and member of the Project Committee of the German National Genome Research Network and provides here a brief introduction to the mouse as a model for diseases and functional analysis of genes and proteins. Throughout, he focuses on the characterization of mouse models using the latest phenotyping methods, with the different areas presented in a clearly structured and easily accessible manner.
Author(s): Martin Hrabé de Angelis, Pierre Chambon, Steve Brown
Edition: 1
Publisher: Wiley-VCH
Year: 2006
Language: English
Pages: 347
Tags: Биологические дисциплины;Генетика;
Cover......Page 1
Standards of Mouse Model Phenotyping......Page 2
Copyright......Page 4
Foreword......Page 5
Table of Contents......Page 7
Preface......Page 16
List of Contributors......Page 19
1 Characterizing Hearing in Mice......Page 25
2 Molecular Phenotyping: Gene Expression Profiling......Page 39
3 Screening for Bone and Cartilage Phenotypes in Mice......Page 59
4 Clinical Chemical Screen......Page 111
5 Exploration of Metabolic and Endocrine Function in the Mouse......Page 132
6 Behavioral and Neurological Phenotyping in the Mouse......Page 157
7 Cardiovascular Disorders: Insights into In Vivo Cardiovascular Phenotyping......Page 198
8 Phenotyping of Host−Pathogen Interactions in Mice......Page 221
9 Animal Models of Nociception......Page 240
10 Mouse Phenotyping: Immunology......Page 255
11 Phenotyping Allergy in the Laboratory Mouse......Page 271
12 Eye Disorders......Page 300
13 EUMORPHIA and the European Mouse Phenotyping Resource for Standardized Screens (EMPReSS)......Page 327
Index......Page 337
